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slm9 histone H3.3-H4 chaperone, HIR complex WD repeat subunit Hip2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540128, updated on 18-Sep-2024

Summary

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Official Symbol
slm9
Official Full Name
histone H3.3-H4 chaperone, HIR complex WD repeat subunit Hip2
Primary source
PomBase:SPBC15D4.03
Locus tag
SPOM_SPBC15D4.03
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
hip2
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Genomic context

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See slm9 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003423.3 (3015532..3018155)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene protein gsf1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene nucleotide-binding domain-containing protein CobW/HypB/UreG

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. HIRA, a conserved histone chaperone, plays an essential role in low-dose stress response via transcriptional stimulation in fission yeast. Chujo M, et al. J Biol Chem, 2012 Jul 6. PMID 22589550, Free PMC Article
  2. The fission yeast HIRA histone chaperone is required for promoter silencing and the suppression of cryptic antisense transcripts. Anderson HE, et al. Mol Cell Biol, 2009 Sep. PMID 19620282, Free PMC Article
  3. Hip3 interacts with the HIRA proteins Hip1 and Slm9 and is required for transcriptional silencing and accurate chromosome segregation. Greenall A, et al. J Biol Chem, 2006 Mar 31. PMID 16428807
  4. The Schizosaccharomyces pombe HIRA-like protein Hip1 is required for the periodic expression of histone genes and contributes to the function of complex centromeres. Blackwell C, et al. Mol Cell Biol, 2004 May. PMID 15121850, Free PMC Article
  5. ATAD2 controls chromatin-bound HIRA turnover. Wang T, et al. Life Sci Alliance, 2021 Dec. PMID 34580178, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Studies indicate that the fission yeast possesses two HIRA proteins Slm9 and Hip1.
    Title: HIRA, a conserved histone chaperone, plays an essential role in low-dose stress response via transcriptional stimulation in fission yeast.
  2. HIRA histone chaperone is required to maintain the protective functions of chromatin.
    Title: The fission yeast HIRA histone chaperone is required for promoter silencing and the suppression of cryptic antisense transcripts.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP-dependent H3-H4 histone complex chaperone activity EXP
Inferred from Experiment
more info
 PubMed 
contributes_to H3-H4 histone complex chaperone activity IC
Inferred by Curator
more info
  
contributes_to nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription elongation-coupled chromatin remodeling IC
Inferred by Curator
more info
  
Component Evidence Code Pubs
part_of HIR complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of HIR complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol HDA PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
histone H3.3-H4 chaperone, HIR complex WD repeat subunit Hip2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    3015532..3018155
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022162.3 → NP_596243.1  histone H3.3-H4 chaperone, HIR complex WD repeat subunit Hip2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596243.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O74309
    Conserved Domains (4) summary
    COG2319
    Location:43 → 396
    WD40; WD40 repeat [General function prediction only]
    pfam07569
    Location:528 → 735
    Hira; TUP1-like enhancer of split
    sd00039
    Location:107 → 147
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:50 → 354
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version

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