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arc3 ARP2/3 actin-organizing complex subunit Arc21 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540144, updated on 18-Sep-2024

Summary

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Official Symbol
arc3
Official Full Name
ARP2/3 actin-organizing complex subunit Arc21
Primary source
PomBase:SPBC1778.08c
Locus tag
SPOM_SPBC1778.08C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
arc18; arc21
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Genomic context

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See arc3 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003423.3 (3111115..3112237, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene fimbrin Neighboring gene ncRNA Neighboring gene carnosine N-methyltransferase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene GTPase-activating protein Neighboring gene ncRNA Neighboring gene serine/threonine protein kinase Ppk21/Pdk1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Schizosaccharomyces pombe Arc3 is a conserved subunit of the Arp2/3 complex required for polarity, actin organization, and endocytosis. Cabrera R, et al. Yeast, 2011 Jun. PMID 21449051, Free PMC Article
  2. Conformational changes in Arp2/3 complex induced by ATP, WASp-VCA, and actin filaments. Espinoza-Sanchez S, et al. Proc Natl Acad Sci U S A, 2018 Sep 11. PMID 30150414, Free PMC Article
  3. A mutant of Arp2p causes partial disassembly of the Arp2/3 complex and loss of cortical actin function in fission yeast. Morrell JL, et al. Mol Biol Cell, 1999 Dec. PMID 10588653, Free PMC Article
  4. Cryo-EM structures reveal how phosphate release from Arp3 weakens actin filament branches formed by Arp2/3 complex. Chavali SS, et al. Nat Commun, 2024 Mar 6. PMID 38448439, Free PMC Article
  5. Structure and biochemical properties of fission yeast Arp2/3 complex lacking the Arp2 subunit. Nolen BJ, et al. J Biol Chem, 2008 Sep 26. PMID 18640983, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data suggest that Arc3p is an evolutionarily conserved subunit of the Arp2/3 complex required for proper F-actin organization and efficient endocytosis.
    Title: Schizosaccharomyces pombe Arc3 is a conserved subunit of the Arp2/3 complex required for polarity, actin organization, and endocytosis.
  2. These data suggest that proteasomes display Arc3-dependent mobility in the cell, and mobile proteasomes can efficiently access substrates throughout the cell, allowing them to effectively regulate cell-compartment-specific activities.
    Title: Proteasome nuclear import mediated by Arc3 can influence efficient DNA damage repair and mitosis in Schizosaccharomyces pombe.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables actin filament binding EXP
Inferred from Experiment
more info
 PubMed 
enables actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Arp2/3 complex-mediated actin nucleation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in actin cortical patch assembly IC
Inferred by Curator
more info
  
involved_in actin cortical patch organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in actin filament branching EXP
Inferred from Experiment
more info
 PubMed 
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment or maintenance of cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Arp2/3 protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Arp2/3 protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in actin cortical patch IDA
Inferred from Direct Assay
more info
 PubMed 
NOT is_active_in actin filament bundle IDA
Inferred from Direct Assay
more info
 PubMed 
NOT is_active_in actomyosin contractile ring IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell division site HDA PubMed 
is_active_in cell tip HDA PubMed 
is_active_in cytosol HDA PubMed 
is_active_in nucleus HDA PubMed 

General protein information

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Preferred Names
ARP2/3 actin-organizing complex subunit Arc21

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    3111115..3112237 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022213.3 → NP_596291.1  ARP2/3 actin-organizing complex subunit Arc21 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596291.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9Y7J4
    Conserved Domains (1) summary
    pfam04062
    Location:1 → 174
    P21-Arc; ARP2/3 complex ARPC3 (21 kDa) subunit
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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