dnm1 mitochondrial dynamin family scission GTPase Dnm1 [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

Gene symbol: dnm1
Gene description: mitochondrial dynamin family scission GTPase Dnm1
Primary source: PomBase:SPBC12C2.08
Locus tag: SPOM_SPBC12C2.08
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Chromosome II - NC_003423.3 Genomic Context describing neighboring genes

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dnm1 deletion blocks mitochondrial fragmentation in Deltafzo1 cells.
Title: dnm1 deletion blocks mitochondrial fragmentation in Δfzo1 cells.
dynamin GTPase Dnm1 is required for promoting mitochondrial fragmentation.
Title: Glucose starvation induces mitochondrial fragmentation depending on the dynamin GTPase Dnm1/Drp1 in fission yeast.
the association of mitochondria with microtubules physically impedes the assembly of the fission protein Dnm1 around mitochondria, resulting in inhibition of mitochondrial fission.
Title: Association of mitochondria with microtubules inhibits mitochondrial fission by precluding assembly of the fission protein Dnm1.
results are consistent with a model of vacuole fission in which Vps1 creates a tubule of an appropriate diameter for subsequent scission by Dnm1
Title: The dynamin-related protein Vps1 regulates vacuole fission, fusion and tubulation in the fission yeast, Schizosaccharomyces pombe.
Dnm1 mediates mitochondrial fission during interphasic growth and at cell division.
Title: The dynamin related protein Dnm1 fragments mitochondria in a microtubule-dependent manner during the fission yeast cell cycle.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GTP binding	ISM Inferred from Sequence Model more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables membrane scission GTPase motor activity	TAS Traceable Author Statement more info	PubMed
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of mitochondrion localization, microtubule-mediated	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular distribution of mitochondria	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial fission	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial membrane fission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion inheritance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peroxisome fission	IBA Inferred from Biological aspect of Ancestor more info
involved_in peroxisome organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vacuole fission	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
NOT is_active_in actin cortical patch	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell division site	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info

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