U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

gpx1 H2O2 scavenger glutathione peroxidase Gpx1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540222, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
gpx1
Official Full Name
H2O2 scavenger glutathione peroxidase Gpx1
Primary source
PomBase:SPBC32F12.03c
Locus tag
SPOM_SPBC32F12.03C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See gpx1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003423.3 (2788863..2789587, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Ski complex WD repeat subunit Ski8 Neighboring gene ncRNA Neighboring gene protein Gem7 Neighboring gene ncRNA Neighboring gene tRNA-Thr

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Schizosaccharomyces pombe homologue of glutathione peroxidase, which does not contain selenocysteine, is induced by several stresses and works as an antioxidant. Yamada K, et al. Yeast, 1999 Aug. PMID 10455235
  2. Gpx1 is a stationary phase-specific thioredoxin peroxidase in fission yeast. Lee SY, et al. Biochem Biophys Res Commun, 2008 Feb 29. PMID 18162174
  3. Distinct functional roles of peroxiredoxin isozymes and glutathione peroxidase from fission yeast, Schizosaccharomyces pombe. Kim JS, et al. BMB Rep, 2010 Mar. PMID 20356456
  4. Dissection of a redox relay: H2O2-dependent activation of the transcription factor Pap1 through the peroxidatic Tpx1-thioredoxin cycle. Calvo IA, et al. Cell Rep, 2013 Dec 12. PMID 24316080
  5. A genetic approach to study H2O2 scavenging in fission yeast--distinct roles of peroxiredoxin and catalase. Paulo E, et al. Mol Microbiol, 2014 Apr. PMID 24521463

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Glutathione peroxidase inhibited thermal aggregation of citrate synthase, but BCP failed to inhibit the aggregation.
    Title: Distinct functional roles of peroxiredoxin isozymes and glutathione peroxidase from fission yeast, Schizosaccharomyces pombe.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
NOT enables glutathione peroxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables thioredoxin peroxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables thioredoxin peroxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables thioredoxin-dependent peroxiredoxin activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell redox homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular detoxification of hydrogen peroxide IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hydrogen peroxide catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm HDA PubMed 
is_active_in cytosol HDA PubMed 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
H2O2 scavenger glutathione peroxidase Gpx1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    2788863..2789587 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022065.3 → NP_596146.1  H2O2 scavenger glutathione peroxidase Gpx1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596146.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O59858
    Conserved Domains (1) summary
    COG0386
    Location:1 → 158
    BtuE; Glutathione peroxidase, house-cleaning role in reducing lipid peroxides [Defense mechanisms, Lipid transport and metabolism]
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials