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pch1 P-TEFB-associated cyclin T Pch1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540237, updated on 18-Sep-2024

Summary

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Official Symbol
pch1
Official Full Name
P-TEFB-associated cyclin T Pch1
Primary source
PomBase:SPBC32F12.06
Locus tag
SPOM_SPBC32F12.06
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See pch1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003423.3 (2794821..2797457)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene gamma-tubulin Gtb1 Neighboring gene protein Cwf12 Neighboring gene MARCH family ubiquitin-protein ligase E3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DASH complex subunit Duo1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pch1(+), a second essential C-type cyclin gene in Schizosaccharomyces pombe. Furnari BA, et al. J Biol Chem, 1997 May 2. PMID 9115279
  2. Characterization of the Schizosaccharomyces pombe Cdk9/Pch1 protein kinase: Spt5 phosphorylation, autophosphorylation, and mutational analysis. Pei Y, et al. J Biol Chem, 2003 Oct 31. PMID 12904290
  3. A Cdk9-PP1 switch regulates the elongation-termination transition of RNA polymerase II. Parua PK, et al. Nature, 2018 Jun. PMID 29899453, Free PMC Article
  4. Cyclin-dependent kinase 9 (Cdk9) of fission yeast is activated by the CDK-activating kinase Csk1, overlaps functionally with the TFIIH-associated kinase Mcs6, and associates with the mRNA cap methyltransferase Pcm1 in vivo. Pei Y, et al. Mol Cell Biol, 2006 Feb. PMID 16428435, Free PMC Article
  5. Interactions between fission yeast Cdk9, its cyclin partner Pch1, and mRNA capping enzyme Pct1 suggest an elongation checkpoint for mRNA quality control. Pei Y, et al. J Biol Chem, 2003 Feb 28. PMID 12475973

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase activator activity EXP
Inferred from Experiment
more info
 PubMed 
enables cyclin-dependent protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of DNA-templated transcription, elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signaling NAS
Non-traceable Author Statement
more info
  
Component Evidence Code Pubs
part_of P-TEFb complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of cyclin-dependent protein kinase holoenzyme complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cyclin-dependent protein kinase holoenzyme complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of cyclin/CDK positive transcription elongation factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol HDA PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
P-TEFB-associated cyclin T Pch1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    2794821..2797457
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001355788.2 → NP_001342735.1  P-TEFB-associated cyclin T Pch1 [Schizosaccharomyces pombe]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O74627, P87075
    Conserved Domains (1) summary
    COG5333
    Location:1 → 323
    CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]
Nucleotide Protein
Heading Accession and Version

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