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srb4 mediator complex subunit Med17 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540294, updated on 18-Sep-2024

Summary

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Official Symbol
srb4
Official Full Name
mediator complex subunit Med17
Primary source
PomBase:SPBC31F10.04c
Locus tag
SPOM_SPBC31F10.04C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
med17
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Genomic context

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See srb4 in Genome Data Viewer
Location:
chromosome: II
Exon count:
3
Sequence:
Chromosome: II; NC_003423.3 (3757414..3759416, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene transcription factor TFIIH complex subunit Tfb2 Neighboring gene acyl-CoA thioesterase Neighboring gene glutathione-specific gamma-glutamylcyclotransferase Ggg1 Neighboring gene protein mug37 Neighboring gene ADP-ribosylation factor Sar1 Neighboring gene ncRNA Neighboring gene protein lsb5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mammalian transcription activation domains of VP16, AP2 and CTF activate transcription in a whole cell extract from Schizosaccharomyces pombe through the SRB/mediator. Tamayo E, et al. Yeast, 2005 May. PMID 15942925
  2. The Soh1/MED31 protein is an ancient component of Schizosaccharomyces pombe and Saccharomyces cerevisiae Mediator. Linder T, et al. J Biol Chem, 2004 Nov 19. PMID 15356001
  3. Structure of the Mediator head module. Larivière L, et al. Nature, 2012 Dec 20. PMID 23123849
  4. A chromatin-remodeling protein is a component of fission yeast mediator. Khorosjutina O, et al. J Biol Chem, 2010 Sep 24. PMID 20622008, Free PMC Article
  5. Cyclin C influences the timing of mitosis in fission yeast. Banyai G, et al. Mol Biol Cell, 2017 Jul 1. PMID 28515143, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. findings show that the activation of transcription by VP16, AP2 and CTF is through the mediator srb4, since depletion of Srb4 inhibits activated transcription but does not inhibit basal transcription
    Title: Mammalian transcription activation domains of VP16, AP2 and CTF activate transcription in a whole cell extract from Schizosaccharomyces pombe through the SRB/mediator.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity EXP
Inferred from Experiment
more info
 PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription initiation by RNA polymerase II EXP
Inferred from Experiment
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription initiation at RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of core mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mediator complex subunit Med17

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    3757414..3759416 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022487.3 → NP_596566.1  mediator complex subunit Med17 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596566.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P87306
    Conserved Domains (1) summary
    pfam10156
    Location:8 → 452
    Med17; Subunit 17 of Mediator complex
Nucleotide Protein
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