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ade9 trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540300, updated on 18-Sep-2024

Summary

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Official Symbol
ade9
Official Full Name
trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase
Primary source
PomBase:SPBC2G2.08
Locus tag
SPOM_SPBC2G2.08
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
min6
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Genomic context

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See ade9 in Genome Data Viewer
Location:
chromosome: II
Exon count:
2
Sequence:
Chromosome: II; NC_003423.3 (3448906..3452766)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene mitochondrial 37S ribosomal protein bS1m Neighboring gene ncRNA Neighboring gene cyclin Crs1 Neighboring gene protein mug110 Neighboring gene N-myristoyltransferase 1 Neighboring gene deoxycytidylate deaminase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nucleocytoplasmic transport in the midzone membrane domain controls yeast mitotic spindle disassembly. Lucena R, et al. J Cell Biol, 2015 May 11. PMID 25963819, Free PMC Article
  2. Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase. Chen JS, et al. Mol Cell Proteomics, 2013 May. PMID 23297348, Free PMC Article
  3. Expanded Interactome of the Intrinsically Disordered Protein Dss1. Schenstrøm SM, et al. Cell Rep, 2018 Oct 23. PMID 30355493, Free PMC Article
  4. Chromatin remodeller Fun30(Fft3) induces nucleosome disassembly to facilitate RNA polymerase II elongation. Lee J, et al. Nat Commun, 2017 Feb 20. PMID 28218250, Free PMC Article
  5. ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Matsuyama A, et al. Nat Biotechnol, 2006 Jul. PMID 16823372

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding ISM
Inferred from Sequence Model
more info
  
enables formate-tetrahydrofolate ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables methenyltetrahydrofolate cyclohydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylenetetrahydrofolate dehydrogenase (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in 10-formyltetrahydrofolate biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in folic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in tetrahydrofolate interconversion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    3448906..3452766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022356.3 → NP_596437.2  trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596437.2

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O43007
    Conserved Domains (4) summary
    cd01080
    Location:150 → 319
    NAD_bind_m-THF_DH_Cyclohyd; NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
    COG0190
    Location:38 → 325
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    pfam00763
    Location:38 → 155
    THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
    pfam01268
    Location:342 → 972
    FTHFS; Formate--tetrahydrofolate ligase
Nucleotide Protein
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