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clr6 class 1 histone deacetylase Clr6 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540368, updated on 18-Sep-2024

Summary

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Official Symbol
clr6
Official Full Name
class 1 histone deacetylase Clr6
Primary source
PomBase:SPBC36.05c
Locus tag
SPOM_SPBC36.05C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See clr6 in Genome Data Viewer
Location:
chromosome: II
Exon count:
14
Sequence:
Chromosome: II; NC_003423.3 (849345..851476, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene spermidine family transporter Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene cysteine synthase Neighboring gene ncRNA Neighboring gene ER farnesyl pyrophosphate synthetase Erg20 Neighboring gene COG complex subunit Cog2 Neighboring gene elongator subunit Iki3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Highly condensed chromatins are formed adjacent to subtelomeric and decondensed silent chromatin in fission yeast. Matsuda A, et al. Nat Commun, 2015 Jul 24. PMID 26205977, Free PMC Article
  2. Involvement of fission yeast Clr6-HDAC in regulation of the checkpoint kinase Cds1. Kunoh T, et al. Nucleic Acids Res, 2008 Jun. PMID 18440981, Free PMC Article
  3. Global effects on gene expression in fission yeast by silencing and RNA interference machineries. Hansen KR, et al. Mol Cell Biol, 2005 Jan. PMID 15632061, Free PMC Article
  4. A new role for the transcriptional corepressor SIN3; regulation of centromeres. Silverstein RA, et al. Curr Biol, 2003 Jan 8. PMID 12526748
  5. Inhibition of type I histone deacetylase increases resistance of checkpoint-deficient cells to genotoxic agents through mitotic delay. Alao JP, et al. Mol Cancer Ther, 2009 Sep. PMID 19723888

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rbm10 facilitates heterochromatin assembly via the Clr6 HDAC complex.
    Title: Rbm10 facilitates heterochromatin assembly via the Clr6 HDAC complex.
  2. Data describe a mechanism for the transcriptional regulation of the general amino acid permease gene per1, suggest a role for Clr6 in transcriptional regulation of per1, and indicate that Oca2 is a repressor of per1.
    Title: Transcriptional activation of the general amino acid permease gene per1 by the histone deacetylase Clr6 Is regulated by Oca2 kinase.
  3. Clr6-HDAC (histone deacetylase) regulates the checkpoint kinase Cds1 when DNA replication encounters a stressful condition.
    Title: Involvement of fission yeast Clr6-HDAC in regulation of the checkpoint kinase Cds1.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables histone H3K14 deacetylase activity EXP
Inferred from Experiment
more info
 PubMed 
enables histone H3K14 deacetylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone H3K9 deacetylase activity EXP
Inferred from Experiment
more info
 PubMed 
enables histone H3K9 deacetylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone H4K12 deacetylase activity EXP
Inferred from Experiment
more info
 PubMed 
enables histone H4K12 deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H4K16 deacetylase activity EXP
Inferred from Experiment
more info
 PubMed 
enables histone H4K16 deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H4K16 deacetylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone H4K48 deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H4K5 deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone deacetylase activity EXP
Inferred from Experiment
more info
 PubMed 
enables histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein lysine deacetylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in epigenetic regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription initiation-coupled chromatin remodeling IC
Inferred by Curator
more info
  
Component Evidence Code Pubs
part_of Rpd3L complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Rpd3L-Expanded complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Rpd3L-Expanded complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Rpd3S complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
NOT is_active_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
class 1 histone deacetylase Clr6

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    849345..851476 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021241.3 → NP_595333.1  class 1 histone deacetylase Clr6 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_595333.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O59702
    Conserved Domains (2) summary
    cd10004
    Location:5 → 379
    RPD3-like; reduced potassium dependency-3 (RPD3)-like
    PTZ00063
    Location:5 → 403
    PTZ00063; histone deacetylase; Provisional
Nucleotide Protein
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Gene LinkOut

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