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lsm4 U6 snRNP-associated protein Lsm4 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540475, updated on 18-Sep-2024

Summary

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Official Symbol
lsm4
Official Full Name
U6 snRNP-associated protein Lsm4
Primary source
PomBase:SPBC30D10.06
Locus tag
SPOM_SPBC30D10.06
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See lsm4 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003423.3 (3086053..3088916, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ER membrane organization protein, HVA22/TB2/DP1 family protein Neighboring gene ncRNA Neighboring gene DNA repair protein Neighboring gene biotin-protein ligase Neighboring gene ncRNA Neighboring gene sepiapterin reductase Neighboring gene chaperone protein Mzm1 Neighboring gene ncRNA Neighboring gene replication fork protection complex subunit Swi3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Quality-Control Mechanism for Telomerase RNA Folding in the Cell. Hu X, et al. Cell Rep, 2020 Dec 29. PMID 33378677
  2. Crystal structures of Lsm3, Lsm4 and Lsm5/6/7 from Schizosaccharomyces pombe. Wu D, et al. PLoS One, 2012. PMID 22615807, Free PMC Article
  3. Pof8 is a La-related protein and a constitutive component of telomerase in fission yeast. Páez-Moscoso DJ, et al. Nat Commun, 2018 Feb 8. PMID 29422664, Free PMC Article
  4. Molecular basis for the distinct cellular functions of the Lsm1-7 and Lsm2-8 complexes. Montemayor EJ, et al. RNA, 2020 Oct. PMID 32518066, Free PMC Article
  5. LARP7 family proteins have conserved function in telomerase assembly. Collopy LC, et al. Nat Commun, 2018 Feb 8. PMID 29422501, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by PomBase

Function Evidence Code Pubs
contributes_to RNA folding chaperone EXP
Inferred from Experiment
more info
 PubMed 
enables U2 snRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables U6 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in P-body assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA cis splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear-transcribed mRNA catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in spliceosomal snRNP assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in telomerase holoenzyme complex assembly TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of Lsm1-7-Pat1 complex EXP
Inferred from Experiment
more info
 PubMed 
part_of Lsm2-8 complex EXP
Inferred from Experiment
more info
 PubMed 
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2 snRNP EXP
Inferred from Experiment
more info
 PubMed 
part_of U4/U6 x U5 tri-snRNP complex ISO
Inferred from Sequence Orthology
more info
  
part_of U5 snRNP IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U6 snRNP EXP
Inferred from Experiment
more info
 PubMed 
part_of U6 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol HDA PubMed 
is_active_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus HDA PubMed 
part_of spliceosomal tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of telomerase holoenzyme complex TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
U6 snRNP-associated protein Lsm4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    3086053..3088916 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001355800.2 → NP_001342832.1  U6 snRNP-associated protein Lsm4 [Schizosaccharomyces pombe]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O14352
    Conserved Domains (1) summary
    cd01723
    Location:2 → 77
    LSm4; Like-Sm protein 4
Nucleotide Protein
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