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dip1 endocytosis protein Dip1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540504, updated on 18-Sep-2024

Summary

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Official Symbol
dip1
Official Full Name
endocytosis protein Dip1
Primary source
PomBase:SPBC24C6.10c
Locus tag
SPOM_SPBC24C6.10C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See dip1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
3
Sequence:
Chromosome: II; NC_003423.3 (2341402..2343170, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene cytochrome c oxidase subunit VIb related protein Neighboring gene G10 protein Neighboring gene DNA mismatch repair protein Neighboring gene ncRNA Neighboring gene 4-amino-4-deoxychorismate lyase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis of functional surfaces on the actin nucleation promoting factor Dip1 required for Arp2/3 complex activation and endocytic actin network assembly. Liu SL, et al. J Biol Chem, 2022 Jun. PMID 35533728, Free PMC Article
  2. Synergy between Wsp1 and Dip1 may initiate assembly of endocytic actin networks. Balzer CJ, et al. Elife, 2020 Nov 12. PMID 33179595, Free PMC Article
  3. Dip1 Co-opts Features of Branching Nucleation to Create Linear Actin Filaments that Activate WASP-Bound Arp2/3 Complex. Balzer CJ, et al. Curr Biol, 2018 Dec 3. PMID 30471998, Free PMC Article
  4. Dip1 defines a class of Arp2/3 complex activators that function without preformed actin filaments. Wagner AR, et al. Curr Biol, 2013 Oct 21. PMID 24120641, Free PMC Article
  5. Characterization of dip1p reveals a switch in Arp2/3-dependent actin assembly for fission yeast endocytosis. Basu R, et al. Curr Biol, 2011 Jun 7. PMID 21620704, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Analysis of functional surfaces on the actin nucleation promoting factor Dip1 required for Arp2/3 complex activation and endocytic actin network assembly.
    Title: Analysis of functional surfaces on the actin nucleation promoting factor Dip1 required for Arp2/3 complex activation and endocytic actin network assembly.
  2. Synergy between Wsp1 and Dip1 may initiate assembly of endocytic actin networks.
    Title: Synergy between Wsp1 and Dip1 may initiate assembly of endocytic actin networks.
  3. Dip1, the S. pombe WISH/DIP/SPIN90 (WDS) protein, co-opts features of branching nucleation to activate Arp2/3 complex. Specifically, it activates Arp2/3 complex to nucleate linear filaments analogous to the branch created by WASP-mediated activation.
    Title: Dip1 Co-opts Features of Branching Nucleation to Create Linear Actin Filaments that Activate WASP-Bound Arp2/3 Complex.
  4. The mechanism by which Dip1 and other WISH/DIP/SPIN90 proteins can provide seed filaments to Arp2/3 complex to serve as master switches in initiating branched actin assembly. This mechanism is distinct from other known activators of Arp2/3 complex.
    Title: Dip1 defines a class of Arp2/3 complex activators that function without preformed actin filaments.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables Arp2/3 complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Arp2/3 complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in Arp2/3 complex-mediated actin nucleation EXP
Inferred from Experiment
more info
 PubMed 
involved_in actin cortical patch assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin cortical patch assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in actin cortical patch localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin cortical patch localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to actin cortical patch IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin cortical patch IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in actin cortical patch IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell division site HDA PubMed 
is_active_in cell tip HDA PubMed 
is_active_in mating projection tip IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
endocytosis protein Dip1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    2341402..2343170 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001356255.2 → NP_001342760.1  endocytosis protein Dip1 [Schizosaccharomyces pombe]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O74771
    Conserved Domains (1) summary
    pfam09431
    Location:199 → 328
    DUF2013; Protein of unknown function (DUF2013)
Nucleotide Protein
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