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mcm2 MCM complex subunit Mcm2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540620, updated on 18-Sep-2024

Summary

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Official Symbol
mcm2
Official Full Name
MCM complex subunit Mcm2
Primary source
PomBase:SPBC4.04c
Locus tag
SPOM_SPBC4.04C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
cdc19; nda1
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Genomic context

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See mcm2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
2
Sequence:
Chromosome: II; NC_003423.3 (1191208..1194142, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene COPII-coated vesicle-associated protein Sfb3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ubiquitin protein ligase E3 component mlo2 Neighboring gene acid phosphatase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Bioinformatical dissection of fission yeast DNA replication origins. Masuda K, et al. Open Biol, 2020 Jul. PMID 32692956, Free PMC Article
  2. Fission yeast Nda1 and Nda4, MCM homologs required for DNA replication, are constitutive nuclear proteins. Okishio N, et al. J Cell Sci, 1996 Feb. PMID 8838655
  3. The fission yeast cdc19+ gene encodes a member of the MCM family of replication proteins. Forsburg SL, et al. J Cell Sci, 1994 Oct. PMID 7876346
  4. Essential role of MCM proteins in premeiotic DNA replication. Lindner K, et al. Mol Biol Cell, 2002 Feb. PMID 11854402, Free PMC Article
  5. Reduced dosage of a single fission yeast MCM protein causes genetic instability and S phase delay. Liang DT, et al. J Cell Sci, 1999 Feb. PMID 9914167

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Bioinformatical dissection of fission yeast DNA replication origins.
    Title: Bioinformatical dissection of fission yeast DNA replication origins.
  2. findings showed that Mcm2, 4 and 7 associate with chromatin at about the same stage of anaphase, suggesting that licensing involves the simultaneous binding of these subunits
    Title: Analysis of Mcm2-7 chromatin binding during anaphase and in the transition to quiescence in fission yeast.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
contributes_to 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA replication origin binding ISO
Inferred from Sequence Orthology
more info
  
enables H3-H4 histone complex chaperone activity EXP
Inferred from Experiment
more info
 PubMed 
enables nucleosome binding EXP
Inferred from Experiment
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to single-stranded DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA replication-dependent chromatin assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA unwinding involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in premeiotic DNA replication IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of DNA replication preinitiation complex IC
Inferred by Curator
more info
 PubMed 
part_of MCM complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MCM complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in chromosome, telomeric repeat region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear pre-replicative complex IC
Inferred by Curator
more info
 PubMed 
is_active_in nuclear replication fork IC
Inferred by Curator
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
MCM complex subunit Mcm2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    1191208..1194142 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021388.3 → NP_595477.1  MCM complex subunit Mcm2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_595477.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P40377
    Conserved Domains (4) summary
    smart00350
    Location:295 → 810
    MCM; minichromosome maintenance proteins
    pfam12619
    Location:42 → 187
    MCM2_N; Mini-chromosome maintenance protein 2
    pfam14551
    Location:203 → 315
    MCM_N; MCM N-terminal domain
    cl21455
    Location:529 → 668
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
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