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mag2 DNA-3-methyladenine glycosylase Mag2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540646, updated on 18-Sep-2024

Summary

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Official Symbol
mag2
Official Full Name
DNA-3-methyladenine glycosylase Mag2
Primary source
PomBase:SPBC23G7.11
Locus tag
SPOM_SPBC23G7.11
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See mag2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003423.3 (2120257..2121050)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene NADH-dependent flavin oxidoreductase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene proteasome regulatory subunit Rpt6

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Non-productive DNA damage binding by DNA glycosylase-like protein Mag2 from Schizosaccharomyces pombe. Adhikary S, et al. DNA Repair (Amst), 2013 Mar 1. PMID 23273506, Free PMC Article
  2. Sculpting of DNA at abasic sites by DNA glycosylase homolog mag2. Dalhus B, et al. Structure, 2013 Jan 8. PMID 23245849, Free PMC Article
  3. Involvement of 3-methyladenine DNA glycosylases Mag1p and Mag2p in base excision repair of methyl methanesulfonate-damaged DNA in the fission yeast Schizosaccharomyces pombe. Kanamitsu K, et al. Genes Genet Syst, 2007 Dec. PMID 18270439
  4. Fission yeast homologs of human XPC and CSB, rhp41 and rhp26, are involved in transcription-coupled repair of methyl methanesulfonate-induced DNA damage. Kanamitsu K, et al. Genes Genet Syst, 2011. PMID 21670547
  5. Large scale screening of genetic interaction with sgf73(+) in fission yeast. Guo Y, et al. Yi Chuan, 2014 Jul. PMID 25076038

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Novel insight into the chemical and physical determinants by which Mag2 engages DNA in a catalytically productive manner.
    Title: Non-productive DNA damage binding by DNA glycosylase-like protein Mag2 from Schizosaccharomyces pombe.
  2. The molecular role of Mag2 appears to be apurinic site recognition and protection.
    Title: Sculpting of DNA at abasic sites by DNA glycosylase homolog mag2.
  3. Involvement of 3-methyladenine DNA glycosylases Mag2p in base excision repair of methyl methanesulfonate-damaged DNA in the fission yeast Schizosaccharomyces pombe.(
    Title: Involvement of 3-methyladenine DNA glycosylases Mag1p and Mag2p in base excision repair of methyl methanesulfonate-damaged DNA in the fission yeast Schizosaccharomyces pombe.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-(abasic site) binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables alkylated DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables alkylbase DNA N-glycosylase activity EXP
Inferred from Experiment
more info
 PubMed 
NOT enables alkylbase DNA N-glycosylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
NOT involved_in DNA alkylation repair EXP
Inferred from Experiment
more info
 PubMed 
NOT involved_in base-excision repair EXP
Inferred from Experiment
more info
 PubMed 
involved_in base-excision repair, AP site formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
NOT involved_in nucleotide-excision repair EXP
Inferred from Experiment
more info
 PubMed 
NOT involved_in recombinational repair EXP
Inferred from Experiment
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-DNA complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DNA-3-methyladenine glycosylase Mag2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    2120257..2121050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021775.3 → NP_595869.1  DNA-3-methyladenine glycosylase Mag2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_595869.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O94468
    Conserved Domains (2) summary
    COG0122
    Location:1 → 213
    AlkA; 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and repair]
    pfam00730
    Location:46 → 193
    HhH-GPD; HhH-GPD superfamily base excision DNA repair protein
Nucleotide Protein
Heading Accession and Version

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