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atg7 E1 Atg8 and Atg12 E1 activating enzyme Atg7 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540790, updated on 18-Sep-2024

Summary

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Official Symbol
atg7
Official Full Name
E1 Atg8 and Atg12 E1 activating enzyme Atg7
Primary source
PomBase:SPBC6B1.05c
Locus tag
SPOM_SPBC6B1.05C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See atg7 in Genome Data Viewer
Location:
chromosome: II
Exon count:
7
Sequence:
Chromosome: II; NC_003423.3 (2634227..2636608, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene microtubule-site clamp monopolin complex subunit Mde4 Neighboring gene ncRNA Neighboring gene ubiquitin hydrolase Ubp14 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic regulation of mitotic competence in G(0) quiescent cells. Sajiki K, et al. Sci Adv, 2018 Aug. PMID 30116786, Free PMC Article
  2. Fission yeast Vps1 and Atg8 contribute to oxidative stress resistance. Mikawa T, et al. Genes Cells, 2010 Mar. PMID 20070859
  3. Autophagy is required for efficient meiosis progression and proper meiotic chromosome segregation in fission yeast. Matsuhara H, et al. Genes Cells, 2016 Jan. PMID 26696398
  4. Regulation of inorganic polyphosphate is required for proper vacuolar proteolysis in fission yeast. Sawada N, et al. J Biol Chem, 2021 Jul. PMID 34147496, Free PMC Article
  5. Autophagy-deficient Schizosaccharomyces pombe mutants undergo partial sporulation during nitrogen starvation. Mukaiyama H, et al. Microbiology (Reading), 2009 Dec. PMID 19778961

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP hydrolysis activity IC
Inferred by Curator
more info
  
enables Atg12 activating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Atg8 activating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to nitrogen starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in piecemeal microautophagy of the nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein modification by small protein conjugation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol HDA PubMed 
is_active_in nucleus HDA PubMed 
is_active_in phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in phagophore assembly site membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E1 Atg8 and Atg12 E1 activating enzyme Atg7

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    2634227..2636608 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021998.3 → NP_596084.1  E1 Atg8 and Atg12 E1 activating enzyme Atg7 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596084.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O43069
    Conserved Domains (3) summary
    cd01486
    Location:337 → 624
    Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
    TIGR01381
    Location:9 → 646
    E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
    pfam16420
    Location:7 → 300
    ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
Nucleotide Protein
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Gene LinkOut

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