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pxl1 paxillin-like protein Pxl1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540856, updated on 14-Nov-2024

Summary

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Official Symbol
pxl1
Official Full Name
paxillin-like protein Pxl1
Primary source
PomBase:SPBC4F6.12
Locus tag
SPOM_SPBC4F6.12
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See pxl1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
2
Sequence:
Chromosome: II; NC_003423.3 (2712168..2714207)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene putative guanyl-nucleotide exchange factor Vps901 Neighboring gene asparagine synthase Neighboring gene ncRNA Neighboring gene WD repeat/BOP1NT protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fission yeast paxillin contains two Cdc15 binding motifs for robust recruitment to the cytokinetic ring. Snider CE, et al. Mol Biol Cell, 2022 Apr 1. PMID 35108037, Free PMC Article
  2. Opposite Surfaces of the Cdc15 F-BAR Domain Create a Membrane Platform That Coordinates Cytoskeletal and Signaling Components for Cytokinesis. Snider CE, et al. Cell Rep, 2020 Dec 22. PMID 33357436, Free PMC Article
  3. Cooperation between Paxillin-like Protein Pxl1 and Glucan Synthase Bgs1 Is Essential for Actomyosin Ring Stability and Septum Formation in Fission Yeast. Cortés JC, et al. PLoS Genet, 2015 Jul. PMID 26132084, Free PMC Article
  4. DYRK kinase Pom1 drives F-BAR protein Cdc15 from the membrane to promote medial division. Bhattacharjee R, et al. Mol Biol Cell, 2020 Apr 15. PMID 32101481, Free PMC Article
  5. Paxillin-Mediated Recruitment of Calcineurin to the Contractile Ring Is Required for the Correct Progression of Cytokinesis in Fission Yeast. Martín-García R, et al. Cell Rep, 2018 Oct 16. PMID 30332655

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fission yeast paxillin contains two Cdc15 binding motifs for robust recruitment to the cytokinetic ring.
    Title: Fission yeast paxillin contains two Cdc15 binding motifs for robust recruitment to the cytokinetic ring.
  2. Cdk1 phosphorylation of fission yeast paxillin inhibits its cytokinetic ring localization.
    Title: Cdk1 phosphorylation of fission yeast paxillin inhibits its cytokinetic ring localization.
  3. paxillin homologue Pxl1 modulates Rho1 GTPase signaling and plays a role in the formation and contraction of the actomyosin ring during cytokinesis
    Title: Schizosaccharomyces pombe Pxl1 is a paxillin homologue that modulates Rho1 activity and participates in cytokinesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables F-bar domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables Rho GDP-dissociation inhibitor activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actomyosin contractile ring assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in actomyosin contractile ring organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to mitotic actomyosin contractile ring IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell division site HDA PubMed 
is_active_in cell division site IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in medial cortex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic actomyosin contractile ring IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic actomyosin contractile ring, intermediate layer IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
paxillin-like protein Pxl1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    2712168..2714207
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022029.3 → NP_596112.1  paxillin-like protein Pxl1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596112.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O74398
    Conserved Domains (2) summary
    cd08368
    Location:378 → 428
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    pfam00412
    Location:258 → 314
    LIM; LIM domain
Nucleotide Protein
Heading Accession and Version

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