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trz2 3'-tRNA-processing endonuclease Trz2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540985, updated on 18-Sep-2024

Summary

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Official Symbol
trz2
Official Full Name
3'-tRNA-processing endonuclease Trz2
Primary source
PomBase:SPBC3D6.03c
Locus tag
SPOM_SPBC3D6.03C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
3'-tRNase; sptrz2
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Genomic context

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See trz2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003423.3 (1271776..1274094, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene But2 family protein But2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 40S ribosomal protein eS25 Neighboring gene mitotic spindle checkpoint protein Mad1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overexpression of Schizosaccharomyces pombe tRNA 3'-end processing enzyme Trz2 leads to an increased cellular iron level and apoptotic cell death. Shang J, et al. Fungal Genet Biol, 2019 Jan. PMID 30393157
  2. Partitioning of the nuclear and mitochondrial tRNA 3'-end processing activities between two different proteins in Schizosaccharomyces pombe. Zhang X, et al. J Biol Chem, 2013 Sep 20. PMID 23928301, Free PMC Article
  3. The fission yeast Schizosaccharomyces pombe has two distinct tRNase Z(L)s encoded by two different genes and differentially targeted to the nucleus and mitochondria. Gan X, et al. Biochem J, 2011 Apr 1. PMID 21208191
  4. ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Matsuyama A, et al. Nat Biotechnol, 2006 Jul. PMID 16823372
  5. The genome sequence of Schizosaccharomyces pombe. Wood V, et al. Nature, 2002 Feb 21. PMID 11859360

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overexpression of trz2 but not trz1 is toxic to cells. In the present work, we showed that trz2 overexpression led to apoptotic cell death, as revealed by DAPI and Annexin V-FITC staining. Overexpression of trz2 also caused a loss of mitochondrial membrane potential and an increased reactive oxygen species (ROS) formation
    Title: Overexpression of Schizosaccharomyces pombe tRNA 3'-end processing enzyme Trz2 leads to an increased cellular iron level and apoptotic cell death.
  2. and trz2 are involved in nuclear and mitochondrial tRNA 3'-end processing, respectively.
    Title: Partitioning of the nuclear and mitochondrial tRNA 3'-end processing activities between two different proteins in Schizosaccharomyces pombe.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables 3'-tRNA processing endoribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3'-tRNA processing endoribonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3'-tRNA processing endoribonuclease activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial polycistronic RNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial tRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial tRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA 3'-end processing IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell division site HDA PubMed 
is_active_in cytosol HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
3'-tRNA-processing endonuclease Trz2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    1271776..1274094 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021423.3 → NP_595514.1  3'-tRNA-processing endonuclease Trz2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_595514.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P87168
    Conserved Domains (3) summary
    COG1234
    Location:410 → 670
    ElaC; Ribonuclease BN, tRNA processing enzyme [Translation, ribosomal structure and biogenesis]
    cd07718
    Location:413 → 599
    RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain
    cl23716
    Location:50 → 119
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
Nucleotide Protein
Heading Accession and Version

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