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rpa43 DNA-directed RNA polymerase I complex subunit Rpa43 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540989, updated on 17-Aug-2024

Summary

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Gene symbol
rpa43
Gene description
DNA-directed RNA polymerase I complex subunit Rpa43
Primary source
PomBase:SPBC3B9.07c
Locus tag
SPOM_SPBC3B9.07C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
rpa21
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Genomic context

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See rpa43 in Genome Data Viewer
Location:
chromosome: II
Exon count:
3
Sequence:
Chromosome: II; NC_003423.3 (4000467..4001243, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene protein TIM chaperone Neighboring gene ncRNA Neighboring gene autophagy-associated protein Atg3 Neighboring gene ncRNA Neighboring gene protein mago nashi Neighboring gene ncRNA Neighboring gene ESCRT II complex subunit Vps36

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. [Characteristics of the cDNA of the Schizosaccharomyces pombe rpa43+ gene: structural similarity of the Rpa43 subunit of RNA-polymerase I with the Rpc25 subunit of RNA-polymerase III]. Shpakovskiĭ GV, et al. Bioorg Khim, 1999 Oct. PMID 10645483
  2. The fission yeast RPA21 subunit of RNA polymerase I: an evolutionarily conserved subunit interacting with ribosomal DNA (rDNA) transcription factor Rrn3p for recruitment to rDNA promoter. Imazawa Y, et al. Genes Genet Syst, 2002 Jun. PMID 12207036
  3. The fission yeast protein Ker1p is an ortholog of RNA polymerase I subunit A14 in Saccharomyces cerevisiae and is required for stable association of Rrn3p and RPA21 in RNA polymerase I. Imazawa Y, et al. J Biol Chem, 2005 Mar 25. PMID 15647272
  4. Senataxin homologue Sen1 is required for efficient termination of RNA polymerase III transcription. Rivosecchi J, et al. EMBO J, 2019 Aug 15. PMID 31294478, Free PMC Article
  5. Conserved strategies of RNA polymerase I hibernation and activation. Heiss FB, et al. Nat Commun, 2021 Feb 3. PMID 33536435, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
contributes_to DNA-directed 5'-3' RNA polymerase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in transcription elongation by RNA polymerase I EXP
Inferred from Experiment
more info
 PubMed 
involved_in transcription elongation by RNA polymerase I IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription initiation at RNA polymerase I promoter IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of RNA polymerase I complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase I complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in nucleolus HDA PubMed 
is_active_in nucleus HDA PubMed 

General protein information

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Preferred Names
DNA-directed RNA polymerase I complex subunit Rpa43

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    4000467..4001243 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022587.3 → NP_596665.1  DNA-directed RNA polymerase I complex subunit Rpa43 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596665.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O43036
    Conserved Domains (2) summary
    pfam17875
    Location:83 → 170
    RPA43_OB; RPA43 OB domain in RNA Pol I
    cl04309
    Location:2 → 85
    RNAP_Rpb7_N_like; This conserved domain represents the N-terminal ribonucleoprotein (RNP) domain of the Rpb7 subunit of eukaryotic RNA polymerase (RNAP) II and its homologs, Rpa43 of eukaryotic RNAP I, Rpc25 of eukaryotic RNAP III, and RpoE (subunit E) of archaeal RNAP. ...
Nucleotide Protein
Heading Accession and Version

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