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wis1 MAP kinase kinase Wis1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541055, updated on 22-Jun-2024

Summary

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Gene symbol
wis1
Gene description
MAP kinase kinase Wis1
Locus tag
SPOM_SPBC409.07C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
smf2; spc2; sty2
Old locus tag
SPBC409.07c
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Genomic context

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See wis1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003423.3 (1143731..1146603, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene SCF ubiquitin ligase complex subunit Skp1 Neighboring gene ncRNA Neighboring gene ubiquitin hydrolase Uch2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Heat stress activates fission yeast Spc1/StyI MAPK by a MEKK-independent mechanism. Shiozaki K, et al. Mol Biol Cell, 1998 Jun. PMID 9614178, Free PMC Article
  2. The wis1 signal transduction pathway is required for expression of cAMP-repressed genes in fission yeast. Stettler S, et al. J Cell Sci, 1996 Jul. PMID 8832415
  3. Identification of Cdc37 as a novel regulator of the stress-responsive mitogen-activated protein kinase. Tatebe H, et al. Mol Cell Biol, 2003 Aug. PMID 12861001, Free PMC Article
  4. Cytoplasmic localization of Wis1 MAPKK by nuclear export signal is important for nuclear targeting of Spc1/Sty1 MAPK in fission yeast. Nguyen AN, et al. Mol Biol Cell, 2002 Aug. PMID 12181336, Free PMC Article
  5. The serine/threonine kinase Cmk2 is required for oxidative stress response in fission yeast. Sánchez-Piris M, et al. J Biol Chem, 2002 May 17. PMID 11886858

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase kinase activity EXP
Inferred from Experiment
more info
 PubMed 
enables MAP kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables MAP kinase kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular hyperosmotic response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to osmotic stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in p38MAPK cascade EXP
Inferred from Experiment
more info
 PubMed 
involved_in p38MAPK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in p38MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of silent mating-type cassette heterochromatin formation EXP
Inferred from Experiment
more info
 PubMed 
Component Evidence Code Pubs
part_of Mcs4 RR-MAPKKK complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Mcs4 RR-MAPKKK complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
MAP kinase kinase Wis1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    1143731..1146603 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021367.3 → NP_595457.1  MAP kinase kinase Wis1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_595457.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P33886
    Conserved Domains (2) summary
    cd06622
    Location:318 → 600
    PKc_PBS2_like; Catalytic domain of fungal PBS2-like dual-specificity Mitogen-Activated Protein Kinase Kinases
    smart00220
    Location:322 → 579
    S_TKc; Serine/Threonine protein kinases, catalytic domain
Nucleotide Protein
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