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erf2 palmitoyltransferase Erf2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541058, updated on 17-Aug-2024

Summary

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Gene symbol
erf2
Gene description
palmitoyltransferase Erf2
Primary source
PomBase:SPBC3H7.09
Locus tag
SPOM_SPBC3H7.09
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
mug142
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Genomic context

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See erf2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003423.3 (1865821..1867532, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene protein tam8 Neighboring gene elongator complex subunit Elp6 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene phosphoserine phosphatase Ser2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Distinct functional relevance of dynamic GTPase cysteine methylation in fission yeast. Franco A, et al. Sci Rep, 2017 Jul 20. PMID 28729673, Free PMC Article
  2. Rho2 palmitoylation is required for plasma membrane localization and proper signaling to the fission yeast cell integrity mitogen- activated protein kinase pathway. Sánchez-Mir L, et al. Mol Cell Biol, 2014 Jul. PMID 24820419, Free PMC Article
  3. Regulation of Ras localization and cell transformation by evolutionarily conserved palmitoyltransferases. Young E, et al. Mol Cell Biol, 2014 Feb. PMID 24248599, Free PMC Article
  4. Quantitative control of protein S-palmitoylation regulates meiotic entry in fission yeast. Zhang MM, et al. PLoS Biol, 2013 Jul. PMID 23843742, Free PMC Article
  5. Protein S-palmitoylation regulates different stages of meiosis in Schizosaccharomyces pombe. Pham TV, et al. Life Sci Alliance, 2023 Apr. PMID 36650056, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results shpw that Rho2 is an in vivo substrate for Erf2 palmitoyltransferase.
    Title: Rho2 palmitoylation is required for plasma membrane localization and proper signaling to the fission yeast cell integrity mitogen- activated protein kinase pathway.
  2. Data indicate that sp-Erf2/zDHHC9 palmitoylates Ras proteins in a highly selective manner in the trans-Golgi compartment to facilitate PM targeting via the trans-Golgi network, a role that is most certainly critical for Ras-driven tumorigenesis.
    Title: Regulation of Ras localization and cell transformation by evolutionarily conserved palmitoyltransferases.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-cysteine S-palmitoyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus HDA PubMed 
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
part_of endoplasmic reticulum palmitoyltransferase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
palmitoyltransferase Erf2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    1865821..1867532 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021667.3 → NP_595766.1  palmitoyltransferase Erf2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_595766.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O74384
    Conserved Domains (1) summary
    COG5273
    Location:57 → 350
    COG5273; Uncharacterized protein containing DHHC-type Zn finger [General function prediction only]
Nucleotide Protein
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Gene LinkOut

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Molecular Biology Databases
Research Materials