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int6 translation initiation factor [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541089, updated on 18-Sep-2024

Summary

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Official Symbol
int6
Official Full Name
translation initiation factor
Primary source
PomBase:SPBC646.09c
Locus tag
SPOM_SPBC646.09C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
tif305; yin6
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Genomic context

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See int6 in Genome Data Viewer
Location:
chromosome: II
Exon count:
2
Sequence:
Chromosome: II; NC_003423.3 (938621..940308, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene oxysterol binding protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene U3 snoRNP protein Nop56

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fission yeast Int6 is not essential for global translation initiation, but deletion of int6(+) causes hypersensitivity to caffeine and affects spore formation. Bandyopadhyay A, et al. Mol Biol Cell, 2000 Nov. PMID 11071923, Free PMC Article
  2. The roles of stress-activated Sty1 and Gcn2 kinases and of the protooncoprotein homologue Int6/eIF3e in responses to endogenous oxidative stress during histidine starvation. Nemoto N, et al. J Mol Biol, 2010 Nov 26. PMID 20875427, Free PMC Article
  3. Moe1 and spInt6, the fission yeast homologues of mammalian translation initiation factor 3 subunits p66 (eIF3d) and p48 (eIF3e), respectively, are required for stable association of eIF3 subunits. Bandyopadhyay A, et al. J Biol Chem, 2002 Jan 18. PMID 11705997
  4. Int6 and Moe1 interact with Cdc48 to regulate ERAD and proper chromosome segregation. Otero JH, et al. Cell Cycle, 2010 Jan 1. PMID 20016281, Free PMC Article
  5. Int6/eIF3e promotes general translation and Atf1 abundance to modulate Sty1 MAPK-dependent stress response in fission yeast. Udagawa T, et al. J Biol Chem, 2008 Aug 8. PMID 18502752, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A transcript-specific eIF3 complex mediates global translational control of energy metabolism.
    Title: A Transcript-Specific eIF3 Complex Mediates Global Translational Control of Energy Metabolism.
  2. Results suggest that Cdc48, Yin6 and Moe1 act in the same protein complex to concertedly control ERAD and chromosome segregation.
    Title: Int6 and Moe1 interact with Cdc48 to regulate ERAD and proper chromosome segregation.
  3. the robust protein synthesis promoted by intact eIF3 appears to be a part of the requisites for sound Sty1 MAPK-dependent signaling governed by the activity of the Atf1 transcription factor
    Title: Int6/eIF3e promotes general translation and Atf1 abundance to modulate Sty1 MAPK-dependent stress response in fission yeast.
  4. In this study, proteasome-COP9-initiation factor proteasome subunit, Rpn7, was isolated as a high copy suppressor that rescued the proteasome defects in yin6 null cells.
    Title: Isolation of the Schizosaccharomyces pombe proteasome subunit Rpn7 and a structure-function study of the proteasome-COP9-initiation factor domain.
  5. Data show that Int6 acts to increase the transcriptional activity of Pap1.
    Title: Activation of AP-1-dependent transcription by a truncated translation initiation factor.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in eukaryotic translation initiation factor 3 complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in formation of cytoplasmic translation initiation complex IC
Inferred by Curator
more info
 PubMed 
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of eukaryotic 43S preinitiation complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of eukaryotic 48S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 3 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of eukaryotic translation initiation factor 3 complex, eIF3e IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
translation initiation factor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    938621..940308 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021275.3 → NP_595367.1  translation initiation factor [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_595367.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O94513
    Conserved Domains (2) summary
    pfam09440
    Location:16 → 150
    eIF3_N; eIF3 subunit 6 N terminal domain
    cl02111
    Location:310 → 391
    PCI; PCI domain
Nucleotide Protein
Heading Accession and Version

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