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pla1 mRNA cleavage and polyadenylation specificity factor poly(A) polymerase Pla1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541099, updated on 18-Sep-2024

Summary

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Official Symbol
pla1
Official Full Name
mRNA cleavage and polyadenylation specificity factor poly(A) polymerase Pla1
Primary source
PomBase:SPBC646.04
Locus tag
SPOM_SPBC646.04
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See pla1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003423.3 (928885..931046)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene protein Cwf11 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene glutamyl-tRNA amidotransferase alpha subunit Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene squalene synthase Erg9 Neighboring gene glucan endo-1,3-alpha-glucosidase Agn2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Schizosaccharomyces pombe pla1 gene encodes a poly(A) polymerase and can functionally replace its Saccharomyces cerevisiae homologue. Ohnacker M, et al. Nucleic Acids Res, 1996 Jul 1. PMID 8692700, Free PMC Article
  2. The nuclear poly(A) binding protein of mammals, but not of fission yeast, participates in mRNA polyadenylation. Kühn U, et al. RNA, 2017 Apr. PMID 28096519, Free PMC Article
  3. Importance of polyadenylation in the selective elimination of meiotic mRNAs in growing S. pombe cells. Yamanaka S, et al. EMBO J, 2010 Jul 7. PMID 20512112, Free PMC Article
  4. Red1 promotes the elimination of meiosis-specific mRNAs in vegetatively growing fission yeast. Sugiyama T, et al. EMBO J, 2011 Mar 16. PMID 21317872, Free PMC Article
  5. A novel factor Iss10 regulates Mmi1-mediated selective elimination of meiotic transcripts. Yamashita A, et al. Nucleic Acids Res, 2013 Nov. PMID 23980030, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Whereas PABPN1 strongly increases the activity of its cognate poly(A) polymerase in vitro, Pab2 was unable to stimulate Pla1 to any significant extent.
    Title: The nuclear poly(A) binding protein of mammals, but not of fission yeast, participates in mRNA polyadenylation.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(A) RNA polymerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables poly(A) RNA polymerase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Mei2 nuclear dot complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cleavage body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mRNA cleavage and polyadenylation specificity factor complex IGI
Inferred from Genetic Interaction
more info
 PubMed 
is_active_in nuclear exosome focus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mRNA cleavage and polyadenylation specificity factor poly(A) polymerase Pla1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    928885..931046
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021270.3 → NP_595362.1  mRNA cleavage and polyadenylation specificity factor poly(A) polymerase Pla1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_595362.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q10295, Q9UU09
    Conserved Domains (3) summary
    COG5186
    Location:2 → 566
    PAP1; Poly(A) polymerase Pap1 [RNA processing and modification]
    pfam04926
    Location:352 → 540
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:7 → 350
    PAP_central; Poly(A) polymerase central domain
Nucleotide Protein
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