Cnga2 cyclic nucleotide gated channel subunit alpha 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Cnga2provided by RGD
Full Name: cyclic nucleotide gated channel subunit alpha 2provided by RGD
Primary source: RGD:2367
See related: EnsemblRapid:ENSRNOG00000030119 AllianceGenome:RGD:2367
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cncg4; OCNC1; OLFCH
Summary: Enables cGMP binding activity; identical protein binding activity; and intracellular cyclic nucleotide activated cation channel activity. Involved in membrane depolarization and sensory perception of smell. Located in perikaryon and plasma membrane. Part of intracellular cyclic nucleotide activated cation channel complex. Orthologous to human CNGA2 (cyclic nucleotide gated channel subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 1.6), Brain (RPKM 0.5) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq37

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (154741742..154759814)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (149696999..149715051)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (69878513..69899075, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The major components of the olfactory transduction pathway in the rat choroid plexus have been determined, including odorant receptors, Galphaolf, adenylate cyclase 3 and CNGA2.
Title: 'Smelling' the cerebrospinal fluid: olfactory signaling molecules are expressed in and mediate chemosensory signaling from the choroid plexus.
Data indicate that the two distinct CaM/OLFp complexes existed simultaneously with stable structures.
Title: Binding orientation and specificity of calmodulin to rat olfactory cyclic nucleotide-gated ion channel.
cGMP activated olfactory CNG channels by binding to the two CNGA2 subunits and the CNGA4 subunit.
Title: Differential regulation by cyclic nucleotides of the CNGA4 and CNGB1b subunits in olfactory cyclic nucleotide-gated channels.
Data show that Cnga2 is enriched in the ciliary membrane fraction.
Title: Scaffolding proteins in highly purified rat olfactory cilia membranes.
Cyclic nucleotide-gated channels (CNG1 and CNG2 A subunits) affect membrane potential and excitability of rat medial vestibular nucleus.
Title: Functional role of cyclic nucleotide-gated channels in rat medial vestibular nucleus neurons.
Recombinant CNGA2 channels are expressed at sarcolemma substructures of cardiac myocytes. The cyclic-GMP-gated current through this channel was activated by ANP and BNP, and potentiated by PDE2 inhibition.
Title: Cyclic guanosine monophosphate compartmentation in rat cardiac myocytes.
the pore glutamate of the CNGA2 channel has a role in cytoplasmic and external response to dequalinium
Title: Mutation of the pore glutamate affects both cytoplasmic and external dequalinium block in the rat olfactory CNGA2 channel.
expression of the alpha-subunit of rod- and olfactory-type CNG channels (CNG1 and CNG2, respectively) in the rat medial vestibular nucleus
Title: Expression of cyclic nucleotide-gated channels in the rat medial vestibular nucleus.
mutants of the olfactory cyclic nucleotide-gated (CNG) channel alpha-subunit CNGA2, encoded into adenoviruses, were used to monitor cAMP in adult ventricular myocytes
Title: Negative feedback exerted by cAMP-dependent protein kinase and cAMP phosphodiesterase on subsarcolemmal cAMP signals in intact cardiac myocytes: an in vivo study using adenovirus-mediated expression of CNG channels.
expression pattern of the functional subunit of olfactory-type CNG channels (CNGA2) in vascular tissues
Title: Expression of olfactory-type cyclic nucleotide-gated channel (CNGA2) in vascular tissues.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cAMP binding	IEA Inferred from Electronic Annotation more info
enables cGMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables cGMP binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables intracellularly cAMP-activated cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables intracellularly cAMP-activated cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables intracellularly cGMP-activated cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables intracellularly cGMP-activated cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic ion channel activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in membrane depolarization	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic cation transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sensory perception of smell	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sensory perception of smell	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in ciliary membrane	IEA Inferred from Electronic Annotation more info
located_in ciliary membrane	ISO Inferred from Sequence Orthology more info
part_of intracellular cyclic nucleotide activated cation channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of intracellular cyclic nucleotide activated cation channel complex	IDA Inferred from Direct Assay more info	PubMed
located_in non-motile cilium membrane	IDA Inferred from Direct Assay more info	PubMed
located_in non-motile cilium membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: cyclic nucleotide-gated channel alpha-2; cyclic nucleotide-gated olfactory channel

Names: CNCalpha3; CNG channel alpha-2; CNG-2; CNG2; cyclic nucleotide gated channel 4; cyclic nucleotide gated channel alpha 2; cyclic nucleotide-gated cation channel 2; cyclic nucleotide-gated channel alpha 3; cyclic nucleotide-gated olfactory channel subunit OCNC1; cyclic nucleotide-gated olfactory channel-like; olfactory cyclic nucleotide-gated channel subunit 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001430136.1 → NP_001417065.1 cyclic nucleotide-gated channel alpha-2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

Q00195, Q549G7
NM_012928.3 → NP_037060.3 cyclic nucleotide-gated channel alpha-2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

Q00195, Q549G7

Related

ENSRNOP00000016415.3, ENSRNOT00000016415.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

154741742..154759814

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063279823.1 → XP_063135893.1 cyclic nucleotide-gated olfactory channel isoform X1

UniProtKB/Swiss-Prot

Q00195, Q549G7

UniProtKB/TrEMBL

F1LS43
XM_063279822.1 → XP_063135892.1 cyclic nucleotide-gated olfactory channel isoform X1