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dot2 ESCRT II complex subunit Dot2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541147, updated on 18-Sep-2024

Summary

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Official Symbol
dot2
Official Full Name
ESCRT II complex subunit Dot2
Primary source
PomBase:SPBC651.05c
Locus tag
SPOM_SPBC651.05C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
vps22
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Genomic context

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See dot2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
2
Sequence:
Chromosome: II; NC_003423.3 (1245920..1247077, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein mug166 Neighboring gene uncharacterized protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The fission yeast homolog of the human transcription factor EAP30 blocks meiotic spindle pole body amplification. Jin Y, et al. Dev Cell, 2005 Jul. PMID 15992541
  2. Fission yeast mutants affecting telomere clustering and meiosis-specific spindle pole body integrity. Jin Y, et al. Genetics, 2002 Mar. PMID 11901107, Free PMC Article
  3. Essential roles of class E Vps proteins for sorting into multivesicular bodies in Schizosaccharomyces pombe. Iwaki T, et al. Microbiology (Reading), 2007 Aug. PMID 17660439, Free PMC Article
  4. Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways. Das J, et al. Sci Signal, 2013 May 21. PMID 23695164, Free PMC Article
  5. Large scale screening of genetic interaction with sgf73(+) in fission yeast. Guo Y, et al. Yi Chuan, 2014 Jul. PMID 25076038

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dot2, the fission yeast homolog of the human transcription factor EAP30, negatively regulates meiotic spindle pole body maturation. [dot2]
    Title: The fission yeast homolog of the human transcription factor EAP30 blocks meiotic spindle pole body amplification.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in karyogamy involved in conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in late endosome to vacuole transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of ESCRT II complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol HDA PubMed 
NOT is_active_in meiotic spindle pole body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nuclear body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 

General protein information

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Preferred Names
ESCRT II complex subunit Dot2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    1245920..1247077 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021413.3 → NP_595503.1  ESCRT II complex subunit Dot2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_595503.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O94663
    Conserved Domains (1) summary
    pfam04157
    Location:6 → 225
    EAP30; EAP30/Vps36 family
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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