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ssb1 DNA replication factor A subunit Ssb1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541158, updated on 22-Jun-2024

Summary

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Gene symbol
ssb1
Gene description
DNA replication factor A subunit Ssb1
Locus tag
SPOM_SPBC660.13C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
rad11; rpa1; rpa70
Old locus tag
SPBC660.13c
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Genomic context

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See ssb1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
2
Sequence:
Chromosome: II; NC_003423.3 (219182..221298, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene single-stranded telomeric-binding protein Tgc1 Neighboring gene ncRNA Neighboring gene ergothioneine biosynthesis methyltransferase Egt2 Neighboring gene ncRNA Neighboring gene M phase inhibitor protein kinase Mik1 Neighboring gene ncRNA Neighboring gene cleavage factor complex subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Schizosaccharomyces pombe rad11+ gene encodes the large subunit of replication protein A. Parker AE, et al. Mol Cell Biol, 1997 May. PMID 9111307, Free PMC Article
  2. Replication fork slowing and stalling are distinct, checkpoint-independent consequences of replicating damaged DNA. Iyer DR, et al. PLoS Genet, 2017 Aug. PMID 28806726, Free PMC Article
  3. Cdc24 Is Essential for Long-range End Resection in the Repair of Double-stranded DNA Breaks. Zhang H, et al. J Biol Chem, 2016 Nov 25. PMID 27729451, Free PMC Article
  4. A novel allele of fission yeast rad11 that causes defects in DNA repair and telomere length regulation. Ono Y, et al. Nucleic Acids Res, 2003 Dec 15. PMID 14654689, Free PMC Article
  5. A double-strand break repair component is essential for S phase completion in fission yeast cell cycling. Suto K, et al. Mol Biol Cell, 1999 Oct. PMID 10512870, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The mutation D223Y in Rpa1 leads to telomere shortening and replication defects at lagging-stand telomeres.RPA1 prevents the formation of G-quadruplex structures at lagging-strand telomeres and facilitate telomerase action at telomeres.
    Title: RPA prevents G-rich structure formation at lagging-strand telomeres to allow maintenance of chromosome ends.
  2. A mutant protein, ssb1-418, greatly alleviated the repair and mitotic defects of mutant cut14-Y1. Ssb1 protein formed nucleolar foci in cut14-Y1 cells, but the number of foci was diminished in cut14-Y1 ssb1-418 double mutants.
    Title: Opposing role of condensin hinge against replication protein A in mitosis and interphase through promoting DNA annealing.
  3. Results suggest that in the absence of Taz1 and functional RPA, Pot1 cannot function properly and the helicase activity of Rqh1 promotes telomere loss.
    Title: Fission yeast Taz1 and RPA are synergistically required to prevent rapid telomere loss.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables damaged DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded DNA binding EXP
Inferred from Experiment
more info
 PubMed 
contributes_to single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables single-stranded telomeric DNA binding EXP
Inferred from Experiment
more info
 PubMed 
enables single-stranded telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables telomerase RNA binding EXP
Inferred from Experiment
more info
 PubMed 
enables telomeric DNA binding EXP
Inferred from Experiment
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in premeiotic DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere maintenance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere maintenance via telomerase EXP
Inferred from Experiment
more info
 PubMed 
involved_in telomere maintenance via telomerase IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in telomere maintenance via telomerase IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of DNA replication factor A complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of DNA replication factor A complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in chromosome, telomeric repeat region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm HDA PubMed 
is_active_in cytosol HDA PubMed 
is_active_in nucleus HDA PubMed 
is_active_in site of DNA damage IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA replication factor A subunit Ssb1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    219182..221298 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001020999.3 → NP_595092.1  DNA replication factor A subunit Ssb1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_595092.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q92372, Q92382
    Conserved Domains (5) summary
    cd04474
    Location:181 → 281
    RPA1_DBD_A; RPA1_DBD_A: A subfamily of OB folds corresponding to the second OB fold, the ssDNA-binding domain (DBD)-A, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which ...
    cd04477
    Location:8 → 106
    RPA1N; RPA1N: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be involved in all ...
    TIGR00617
    Location:2 → 607
    rpa1; replication factor-a protein 1 (rpa1)
    pfam08646
    Location:457 → 601
    Rep_fac-A_C; Replication factor-A C terminal domain
    pfam16900
    Location:300 → 397
    REPA_OB_2; Replication protein A OB domain
Nucleotide Protein
Heading Accession and Version

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