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his4 imidazoleglycerol-phosphate synthase [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541224, updated on 22-Jun-2024

Summary

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Gene symbol
his4
Gene description
imidazoleglycerol-phosphate synthase
Locus tag
SPOM_SPBC418.01C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
SPBC887.20c
Old locus tag
SPBC418.01c
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Genomic context

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See his4 in Genome Data Viewer
Location:
chromosome: II
Exon count:
2
Sequence:
Chromosome: II; NC_003423.3 (3581989..3583840, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene transmembrane transporter Neighboring gene ncRNA Neighboring gene SAGA complex subunit Hfi1/Ada1 Neighboring gene ncRNA Neighboring gene Man5GlcNac2-PP-Dol translocation protein Rft1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene NatA N-acetyltransferase complex subunit Neighboring gene protein acl4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caffeine-resistance in S. pombe: mutations in three novel caf genes increase caffeine tolerance and affect radiation sensitivity, fertility, and cell cycle. Benko Z, et al. Curr Genet, 1997 Jun. PMID 9211790
  2. Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, et al. Mol Cell, 2012 Jun 8. PMID 22681890, Free PMC Article
  3. ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Matsuyama A, et al. Nat Biotechnol, 2006 Jul. PMID 16823372
  4. The genome sequence of Schizosaccharomyces pombe. Wood V, et al. Nature, 2002 Feb 21. PMID 11859360
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables glutaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables imidazoleglycerol-phosphate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxo-acid-lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-histidine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol HDA PubMed 
is_active_in nucleus HDA PubMed 

General protein information

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Preferred Names
imidazoleglycerol-phosphate synthase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    3581989..3583840 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022414.3 → NP_596494.2  imidazoleglycerol-phosphate synthase [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596494.2

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O94303, Q9Y7X3
    Conserved Domains (3) summary
    cd01748
    Location:3 → 205
    GATase1_IGP_Synthase; Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS)
    PLN02617
    Location:3 → 541
    PLN02617; imidazole glycerol phosphate synthase hisHF
    COG0107
    Location:227 → 540
    HisF; Imidazole glycerol phosphate synthase subunit HisF [Amino acid transport and metabolism]
Nucleotide Protein
Heading Accession and Version

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