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mto2 gamma tubulin complex linker Mto2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541264, updated on 18-Sep-2024

Summary

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Official Symbol
mto2
Official Full Name
gamma tubulin complex linker Mto2
Primary source
PomBase:SPBC902.06
Locus tag
SPOM_SPBC902.06
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See mto2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
2
Sequence:
Chromosome: II; NC_003423.3 (494679..496423)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene MTREC (exosome adaptor) complex RNA-binding subunit Rmn1 Neighboring gene ncRNA Neighboring gene isocitrate dehydrogenase (NAD+) subunit 2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene dual-specificity MAP kinase phosphatase Pmp1 Neighboring gene 40S ribosomal protein eS12

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Two distinct regions of Mto1 are required for normal microtubule nucleation and efficient association with the gamma-tubulin complex in vivo. Samejima I, et al. J Cell Sci, 2008 Dec 1. PMID 19001497, Free PMC Article
  2. Mto2 multisite phosphorylation inactivates non-spindle microtubule nucleation complexes during mitosis. Borek WE, et al. Nat Commun, 2015 Aug 5. PMID 26243668, Free PMC Article
  3. Activation of the γ-tubulin complex by the Mto1/2 complex. Lynch EM, et al. Curr Biol, 2014 Apr 14. PMID 24704079, Free PMC Article
  4. Efficient formation of bipolar microtubule bundles requires microtubule-bound gamma-tubulin complexes. Janson ME, et al. J Cell Biol, 2005 Apr 25. PMID 15837798, Free PMC Article
  5. Mto2p, a novel fission yeast protein required for cytoplasmic microtubule organization and anchoring of the cytokinetic actin ring. Venkatram S, et al. Mol Biol Cell, 2005 Jun. PMID 15800064, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mto1/2 complex disassembles during mitosis, coincident with hyperphosphorylation of Mto2 protein
    Title: Mto2 multisite phosphorylation inactivates non-spindle microtubule nucleation complexes during mitosis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
contributes_to cytoskeletal protein-membrane anchor activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in interphase microtubule organizing center assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule bundle formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell division site HDA PubMed 
is_active_in cytoplasm HDA PubMed 
is_active_in cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in equatorial microtubule organizing center IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in interphase microtubule organizing center IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic spindle pole body HDA PubMed 
is_active_in mitotic spindle pole body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in static microtubule bundle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
gamma tubulin complex linker Mto2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    494679..496423
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001355846.2 → NP_001342930.1  gamma tubulin complex linker Mto2 [Schizosaccharomyces pombe]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9USP7, Q9UTV6
Nucleotide Protein
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