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orc4 origin recognition complex subunit Orc4 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541298, updated on 18-Sep-2024

Summary

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Official Symbol
orc4
Official Full Name
origin recognition complex subunit Orc4
Primary source
PomBase:SPBP23A10.13
Locus tag
SPOM_SPBP23A10.13
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
orp4
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Genomic context

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See orc4 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003423.3 (2025388..2028676)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene FRG1 family mRNA-processing protein Neighboring gene RNA polymerase II transcription elongation factor Ell1 Neighboring gene ncRNA Neighboring gene tRNA-Asn

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The fission yeast homologue of Orc4p binds to replication origin DNA via multiple AT-hooks. Chuang RY, et al. Proc Natl Acad Sci U S A, 1999 Mar 16. PMID 10077566, Free PMC Article
  2. Atomic force microscopic analysis of the binding of the Schizosaccharomyces pombe origin recognition complex and the spOrc4 protein with origin DNA. Gaczynska M, et al. Proc Natl Acad Sci U S A, 2004 Dec 28. PMID 15598736, Free PMC Article
  3. Site-specific ORC binding, pre-replication complex assembly and DNA synthesis at Schizosaccharomyces pombe replication origins. Kong D, et al. EMBO J, 2002 Oct 15. PMID 12374757, Free PMC Article
  4. Bioinformatical dissection of fission yeast DNA replication origins. Masuda K, et al. Open Biol, 2020 Jul. PMID 32692956, Free PMC Article
  5. Xenopus origin recognition complex (ORC) initiates DNA replication preferentially at sequences targeted by Schizosaccharomyces pombe ORC. Kong D, et al. EMBO J, 2003 Jul 1. PMID 12840006, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Bioinformatical dissection of fission yeast DNA replication origins.
    Title: Bioinformatical dissection of fission yeast DNA replication origins.
  2. The interaction of the origin recognition complex (ORC) and the Orc4 subunit with origin DNA was examined using atomic force microscopy. ORC binding occurs through Orc4, and 2 turns of DNA appear to wrap around the Orc4 subunit in the ORC complex. [Orc4]
    Title: Atomic force microscopic analysis of the binding of the Schizosaccharomyces pombe origin recognition complex and the spOrc4 protein with origin DNA.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding NAS
Non-traceable Author Statement
more info
  
enables ATP hydrolysis activity ISM
Inferred from Sequence Model
more info
  
enables DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA replication origin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-macromolecule adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA topological change IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of DNA replication preinitiation complex IC
Inferred by Curator
more info
 PubMed 
is_active_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear origin of replication recognition complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear origin of replication recognition complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear pre-replicative complex IC
Inferred by Curator
more info
 PubMed 
is_active_in nuclear replication fork IC
Inferred by Curator
more info
 PubMed 
is_active_in nucleus HDA PubMed 

General protein information

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Preferred Names
origin recognition complex subunit Orc4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    2025388..2028676
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021729.3 → NP_595825.1  origin recognition complex subunit Orc4 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_595825.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9Y794
    Conserved Domains (3) summary
    smart00382
    Location:575 → 741
    AAA; ATPases associated with a variety of cellular activities
    pfam13191
    Location:551 → 716
    AAA_16; AAA ATPase domain
    pfam14629
    Location:754 → 944
    ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus
Nucleotide Protein
Heading Accession and Version

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