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cut14 condensin complex SMC subunit Smc2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541319, updated on 18-Sep-2024

Summary

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Official Symbol
cut14
Official Full Name
condensin complex SMC subunit Smc2
Primary source
PomBase:SPBP4H10.06c
Locus tag
SPOM_SPBP4H10.06C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
smc2
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Genomic context

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See cut14 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003423.3 (2877687..2881368, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene calcium-dependent serine/threonine protein phosphatase calcineurin catalytic subunit Ppb1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene S-adenosylmethionine decarboxylase proenzyme Spe2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ubiquitin-protein ligase E3 Neighboring gene ncRNA Neighboring gene ubiquinol-cytochrome-c reductase complex subunit Qcr10

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fission yeast condensin contributes to interphase chromatin organization and prevents transcription-coupled DNA damage. Kakui Y, et al. Genome Biol, 2020 Nov 5. PMID 33153481, Free PMC Article
  2. Condensin-mediated remodeling of the mitotic chromatin landscape in fission yeast. Kakui Y, et al. Nat Genet, 2017 Oct. PMID 28825727, Free PMC Article
  3. Quantitative analysis of chromosome condensation in fission yeast. Petrova B, et al. Mol Cell Biol, 2013 Mar. PMID 23263988, Free PMC Article
  4. DNA renaturation activity of the SMC complex implicated in chromosome condensation. Sutani T, et al. Nature, 1997 Aug 21. PMID 9285594
  5. Fission yeast cut3 and cut14, members of a ubiquitous protein family, are required for chromosome condensation and segregation in mitosis. Saka Y, et al. EMBO J, 1994 Oct 17. PMID 7957061, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Condensin locates at transcription termination sites in mitosis.
    Title: Condensin locates at transcriptional termination sites in mitosis, possibly releasing mitotic transcripts.
  2. A conditional shutoff allele for the condensin subunit Cut14Smc2 was created and used in a chromosome conformation capture (Hi-C) to study mitotic chromosome condensation. Condensin replaces the interphase landscape of small chromatin domains with fewer but larger domains in mitosis by setting up longer-range, intrachromosomal DNA interactions, which compact and individualize chromosomes.
    Title: Condensin-mediated remodeling of the mitotic chromatin landscape in fission yeast.
  3. identified a novel SMC (structural maintenance of chromosomes) hinge mutant, cut14-Y1, which displayed defects in DNA damage repair and chromosome segregation
    Title: Opposing role of condensin hinge against replication protein A in mitosis and interphase through promoting DNA annealing.
  4. data suggest that Ccq1p and condensins Cut3p and Cut14p collaborate to mediate resolution of telomeres in mitosis and regulate intertelomeric clustering during interphase
    Title: Ccq1p and the condensin proteins Cut3p and Cut14p prevent telomere entanglements in the fission yeast Schizosaccharomyces pombe.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA translocase activity TAS
Traceable Author Statement
more info
 PubMed 
contributes_to DNA-DNA tethering activity EXP
Inferred from Experiment
more info
 PubMed 
contributes_to DNA/DNA annealing activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to topological DNA co-entrapment activity EXP
Inferred from Experiment
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic chromosome condensation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic chromosome condensation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in chromosome, centromeric core domain IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in condensed chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of condensin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of condensin complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in euchromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
condensin complex SMC subunit Smc2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    2877687..2881368 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022099.3 → NP_596180.1  condensin complex SMC subunit Smc2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596180.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P41003, Q9P7E2
    Conserved Domains (4) summary
    cd03273
    Location:1 → 172
    ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins
    smart00968
    Location:522 → 640
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:1 → 1169
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl21455
    Location:1076 → 1170
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
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