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dpb2 DNA polymerase epsilon catalytic subunit B Dpb2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541347, updated on 18-Sep-2024

Summary

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Official Symbol
dpb2
Official Full Name
DNA polymerase epsilon catalytic subunit B Dpb2
Primary source
PomBase:SPBP8B7.14c
Locus tag
SPOM_SPBP8B7.14C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See dpb2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
3
Sequence:
Chromosome: II; NC_003423.3 (3656748..3658930, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene CENP-H-like protein Fta3 Neighboring gene ncRNA Neighboring gene protein vac7 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RBBP6 family ubiquitin-protein ligase E3 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Schizosacchromyces pombe Dpb2 binds to origin DNA early in S phase and is required for chromosomal DNA replication. Feng W, et al. Mol Biol Cell, 2003 Aug. PMID 12925774, Free PMC Article
  2. Identification and cloning of two putative subunits of DNA polymerase epsilon in fission yeast. Spiga MG, et al. Nucleic Acids Res, 2004. PMID 15388803, Free PMC Article
  3. Rad4TopBP1, a scaffold protein, plays separate roles in DNA damage and replication checkpoints and DNA replication. Taricani L, et al. Mol Biol Cell, 2006 Aug. PMID 16723501, Free PMC Article
  4. Ordered assembly of Sld3, GINS and Cdc45 is distinctly regulated by DDK and CDK for activation of replication origins. Yabuuchi H, et al. EMBO J, 2006 Oct 4. PMID 16990792, Free PMC Article
  5. Mcm10 plays an essential role in origin DNA unwinding after loading of the CMG components. Kanke M, et al. EMBO J, 2012 May 2. PMID 22433840, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cdc20 and Dpb2 of the Pol epsilon complex are required for loading of GINS, Cut5, Drc1, and Cdc45 onto replication origins.
    Title: DNA polymerization-independent functions of DNA polymerase epsilon in assembly and progression of the replisome in fission yeast.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
contributes_to double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in CMG complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA strand elongation involved in mitotic DNA replication IC
Inferred by Curator
more info
 PubMed 
involved_in DNA-templated DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in error-prone translesion synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic DNA replication initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of DNA replication preinitiation complex IC
Inferred by Curator
more info
  
is_active_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
part_of epsilon DNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of epsilon DNA polymerase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear replication fork ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus HDA PubMed 

General protein information

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Preferred Names
DNA polymerase epsilon catalytic subunit B Dpb2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    3656748..3658930 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022442.3 → NP_596521.1  DNA polymerase epsilon catalytic subunit B Dpb2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596521.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O94263
    Conserved Domains (1) summary
    pfam04042
    Location:333 → 556
    DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
Nucleotide Protein
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