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shk2 PAK-like kinase Shk2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541468, updated on 18-Sep-2024

Summary

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Official Symbol
shk2
Official Full Name
PAK-like kinase Shk2
Primary source
PomBase:SPAC1F5.09c
Locus tag
SPOM_SPAC1F5.09C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
pak2
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Genomic context

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See shk2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (273152..274921)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ATP-dependent RNA helicase Neighboring gene plasma membrane stretch-activated calcium ion channel Yam8 Neighboring gene protein Lhs1 Neighboring gene protoporphyrinogen oxidase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of Pak2p, a pleckstrin homology domain-containing, p21-activated protein kinase from fission yeast. Sells MA, et al. J Biol Chem, 1998 Jul 17. PMID 9660818
  2. Gamete fusion triggers bipartite transcription factor assembly to block re-fertilization. Vještica A, et al. Nature, 2018 Aug. PMID 30089908
  3. The Schizosaccharomyces pombe Cdc42p GTPase signals through Pak2p and the Mkh1p-Pek1p-Spm1p MAP kinase pathway. Merla A, et al. Curr Genet, 2001 Jun. PMID 11453249
  4. The novel Rho GTPase-activating protein family protein, Rga8, provides a potential link between Cdc42/p21-activated kinase and Rho signaling pathways in the fission yeast, Schizosaccharomyces pombe. Yang P, et al. J Biol Chem, 2003 Dec 5. PMID 14506270
  5. Cloning and characterization of shk2, a gene encoding a novel p21-activated protein kinase from fission yeast. Yang P, et al. J Biol Chem, 1998 Jul 17. PMID 9660817

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding ISM
Inferred from Sequence Model
more info
  
enables lipid binding ISM
Inferred from Sequence Model
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in plasma membrane fusion involved in cytogamy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
PAK-like kinase Shk2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    273152..274921
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018264.1 → NP_592864.1  PAK-like kinase Shk2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_592864.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q10056
    Conserved Domains (4) summary
    smart00220
    Location:309 → 566
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13279
    Location:24 → 120
    PH_Cla4_Ste20; Pleckstrin homology (PH) domain
    cd06614
    Location:308 → 567
    STKc_PAK; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase
    pfam00786
    Location:128 → 182
    PBD; P21-Rho-binding domain
Nucleotide Protein
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