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sen1 helicase Sen1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541556, updated on 18-Sep-2024

Summary

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Official Symbol
sen1
Official Full Name
helicase Sen1
Primary source
PomBase:SPAC6G9.10c
Locus tag
SPOM_SPAC6G9.10C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See sen1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (3262405..3268040, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ubiquitin hydrolase Ubp6 Neighboring gene ncRNA Neighboring gene 60S ribosomal protein eL24 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene synaptobrevin family receptor Neighboring gene CHS5-like protein Cfr1 Neighboring gene bouquet formation protein Bqt1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The sen1(+) gene of Schizosaccharomyces pombe, a homologue of budding yeast SEN1, encodes an RNA and DNA helicase. Kim HD, et al. Biochemistry, 1999 Nov 2. PMID 10545196
  2. Senataxin homologue Sen1 is required for efficient termination of RNA polymerase III transcription. Rivosecchi J, et al. EMBO J, 2019 Aug 15. PMID 31294478, Free PMC Article
  3. RNA processing factors Swd2.2 and Sen1 antagonize RNA Pol III-dependent transcription and the localization of condensin at Pol III genes. Legros P, et al. PLoS Genet, 2014 Nov. PMID 25392932, Free PMC Article
  4. The Nrd1-like protein Seb1 coordinates cotranscriptional 3' end processing and polyadenylation site selection. Lemay JF, et al. Genes Dev, 2016 Jul 1. PMID 27401558, Free PMC Article
  5. CPF-associated phosphatase activity opposes condensin-mediated chromosome condensation. Vanoosthuyse V, et al. PLoS Genet, 2014 Jun. PMID 24945319, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables 5'-3' DNA/RNA helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 5'-3' RNA helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IC
Inferred by Curator
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription termination site sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in termination of RNA polymerase II transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in termination of RNA polymerase III transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
NOT part_of Nrd1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nuclear body IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus HDA PubMed 

General protein information

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Preferred Names
helicase Sen1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    3262405..3268040 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019543.3 → NP_594119.1  helicase Sen1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594119.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q92355
    Conserved Domains (5) summary
    COG1112
    Location:765 → 1641
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam12726
    Location:53 → 693
    SEN1_N; SEN1 N terminal
    pfam13087
    Location:1422 → 1618
    AAA_12; AAA domain
    pfam13245
    Location:1137 → 1212
    AAA_19; Part of AAA domain
    cl21455
    Location:1350 → 1410
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
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