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dnf2 phospholipid-transporting ATPase [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541560, updated on 22-Jun-2024

Summary

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Gene symbol
dnf2
Gene description
phospholipid-transporting ATPase
Locus tag
SPOM_SPAC24B11.12C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Old locus tag
SPAC24B11.12c
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Genomic context

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See dnf2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
2
Sequence:
Chromosome: I; NC_003424.3 (224080..229236, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene chitin synthase regulatory factor-like Chr3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene serine/threonine protein kinase (NDR family) Sid2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene hydroxymethylbilane synthase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yeast and human P4-ATPases transport glycosphingolipids using conserved structural motifs. Roland BP, et al. J Biol Chem, 2019 Feb 8. PMID 30530492, Free PMC Article
  2. The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast. Fontebasso Y, et al. DNA Repair (Amst), 2013 Dec. PMID 24192486, Free PMC Article
  3. The fission yeast FLCN/FNIP complex augments TORC1 repression or activation in response to amino acid (AA) availability. Calvo IA, et al. iScience, 2021 Nov 19. PMID 34805795, Free PMC Article
  4. Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome. Telekawa C, et al. Nucleic Acids Res, 2018 Nov 30. PMID 30321377, Free PMC Article
  5. Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes. Rallis C, et al. Sci Rep, 2017 Mar 10. PMID 28281664, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled intramembrane lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycosylceramide flippase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylcholine flippase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylcholine floppase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylethanolamine flippase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylserine floppase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycolipid translocation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum HDA PubMed 
part_of phospholipid-translocating ATPase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phospholipid-transporting ATPase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    224080..229236 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018250.3 → NP_592849.1  phospholipid-transporting ATPase [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_592849.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q09891, Q9USC3
    Conserved Domains (5) summary
    COG4087
    Location:989 → 1045
    COG4087; Soluble P-type ATPase [General function prediction only]
    TIGR01652
    Location:85 → 1295
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam13246
    Location:678 → 773
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:85 → 129
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:1038 → 1287
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
Nucleotide Protein
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