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CXorf58 chromosome X open reading frame 58 [ Homo sapiens (human) ]

Gene ID: 254158, updated on 3-Apr-2024

Summary

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Official Symbol
CXorf58provided by HGNC
Official Full Name
chromosome X open reading frame 58provided by HGNC
Primary source
HGNC:HGNC:26356
See related
Ensembl:ENSG00000165182 AllianceGenome:HGNC:26356
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in testis (RPKM 2.2) and thyroid (RPKM 0.1) See more
Orthologs
mouse all
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Genomic context

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Location:
Xp22.11
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (23907932..23939509)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (23491609..23523191)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (23926123..23957626)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chrX:23800811-23802010 Neighboring gene uncharacterized LOC127933115 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chrX:23825194-23826393 Neighboring gene spermidine/spermine N1-acetyltransferase 1 Neighboring gene ribosomal protein L9 pseudogene 7 Neighboring gene apolipoprotein O Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:23900936-23901702 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:23905519-23905696 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20707 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29494 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:23970710-23971248 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:23971249-23971786 Neighboring gene Sharpr-MPRA regulatory region 13558 Neighboring gene kelch like family member 15 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29495 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20708 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20709 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20710 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:24043667-24044171 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:24044172-24044675 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:24045883-24046382 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20713 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29496 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29497 Neighboring gene eukaryotic translation initiation factor 2 subunit gamma

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Progress in the Chromosome-Centric Human Proteome Project as Highlighted in the Annual Special Issue IV. Paik YK, et al. J Proteome Res, 2016 Nov 4. PMID 27809547, Free PMC Article
  2. Functionathon: a manual data mining workflow to generate functional hypotheses for uncharacterized human proteins and its application by undergraduate students. Duek P, et al. Database (Oxford), 2021 Jul 28. PMID 34318869, Free PMC Article
  3. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article
  4. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. Xiao T, et al. Proc Natl Acad Sci U S A, 2018 Jul 31. PMID 29987050, Free PMC Article
  5. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ25444

General protein information

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Preferred Names
uncharacterized protein CXorf58

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016380.1 RefSeqGene

    Range
    5001..36504
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001169574.2 → NP_001163045.1  uncharacterized protein CXorf58 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC079376, AK058173, BC144007
    UniProtKB/TrEMBL
    B7ZLS7

  2. NM_152761.3 → NP_689974.2  uncharacterized protein CXorf58 isoform 1

    See identical proteins and their annotated locations for NP_689974.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC079376, AK058173
    Consensus CDS
    CCDS14209.1
    UniProtKB/Swiss-Prot
    Q96LI9
    UniProtKB/TrEMBL
    B7ZLS7
    Related
    ENSP00000368511.3, ENST00000379211.8

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    23907932..23939509
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545473.3 → XP_011543775.1  uncharacterized protein CXorf58 isoform X1

    See identical proteins and their annotated locations for XP_011543775.1

    UniProtKB/Swiss-Prot
    Q96LI9
    UniProtKB/TrEMBL
    B7ZLS7

  2. XM_011545474.3 → XP_011543776.1  uncharacterized protein CXorf58 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    23491609..23523191
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326756.1 → XP_054182731.1  uncharacterized protein CXorf58 isoform X1

  2. XM_054326757.1 → XP_054182732.1  uncharacterized protein CXorf58 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96LI9.2 GenPept UniProtKB/Swiss-Prot:Q96LI9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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