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smc5 Smc5-6 complex SMC P-loop ATPase subunit Smc5 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541587, updated on 18-Sep-2024

Summary

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Official Symbol
smc5
Official Full Name
Smc5-6 complex SMC P-loop ATPase subunit Smc5
Primary source
PomBase:SPAC14C4.02c
Locus tag
SPOM_SPAC14C4.02C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
spr18
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Genomic context

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See smc5 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003424.3 (5226179..5229793, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene RNA NAD-cap (NAD-forming) hydrolase/RNA pyrophosphohydrolase Din1 Neighboring gene mitophagy receptor Atg43 Neighboring gene ncRNA Neighboring gene 4-aminobutyrate aminotransferase (GABA transaminase) Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DASH complex subunit Dad3 Neighboring gene meiosis-specific serine/threonine protein kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Live-cell single-molecule tracking highlights requirements for stable Smc5/6 chromatin association in vivo. Etheridge TJ, et al. Elife, 2021 Apr 16. PMID 33860765, Free PMC Article
  2. The Smc5/6 Complex: New and Old Functions of the Enigmatic Long-Distance Relative. Aragón L. Annu Rev Genet, 2018 Nov 23. PMID 30476445
  3. DNA-binding properties of Smc6, a core component of the Smc5-6 DNA repair complex. Roy MA, et al. Biochem Biophys Res Commun, 2011 Dec 9. PMID 22086171
  4. Localization of Smc5/6 to centromeres and telomeres requires heterochromatin and SUMO, respectively. Pebernard S, et al. EMBO J, 2008 Nov 19. PMID 18923417, Free PMC Article
  5. Smc5/6 is required for repair at collapsed replication forks. Ampatzidou E, et al. Mol Cell Biol, 2006 Dec. PMID 17030601, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Live-cell single-molecule tracking highlights requirements for stable Smc5/6 chromatin association in vivo.
    Title: Live-cell single-molecule tracking highlights requirements for stable Smc5/6 chromatin association in vivo.
  2. Authors show that the chromatin association and SUMO ligase activity of Smc5-Smc6 require the Nse5-Nse6 heterodimer, explaining how this nonessential cofactor critically supports the DNA repair roles of Smc5-Smc6.
    Title: Brc1 Promotes the Focal Accumulation and SUMO Ligase Activity of Smc5-Smc6 during Replication Stress.
  3. I summarize new research that is beginning to tease out the molecular details of Smc5/6 structure and function, knowledge that will illuminate the nuclear activities of Smc5/6 in the stability and dynamics of eukaryotic genomes
    Title: The Smc5/6 Complex: New and Old Functions of the Enigmatic Long-Distance Relative.
  4. Study shows that the Smc5/6-hinge complex binds preferentially to ssDNA and that this interaction is affected by both 'latch' and 'hub' mutations, suggesting a key role for these unique features in controlling DNA association by the Smc5/6 complex.
    Title: Specialized interfaces of Smc5/6 control hinge stability and DNA association.
  5. The function of the SMC5/6 complex and its mammalian homologs in the cell cycle has not been clarified yet.
    Title: The (elusive) role of the SMC5/6 complex.
  6. Smc5 is a required for homologous recombination in S. pombe.
    Title: Nse1-dependent recruitment of Smc5/6 to lesion-containing loci contributes to the repair defects of mutant complexes.
  7. Smc6 contributes to DNA repair in vivo by targeting the Smc5-6 complex to single-stranded DNA substrates created during the processes of homologous recombination and/or DNA replication.
    Title: DNA-binding properties of Smc6, a core component of the Smc5-6 DNA repair complex.
  8. In an examination of the evolutionary conservation of the Nse3-Nse4 interactions, we find that several MAGE proteins can interact with at least one of the NSE4/EID proteins.
    Title: Interactions between the Nse3 and Nse4 components of the SMC5-6 complex identify evolutionarily conserved interactions between MAGE and EID Families.
  9. Data show that defective cohesin removal is a major determinant of the mitotic lethality of Smc5-Smc6 mutants.
    Title: Smc5-Smc6-dependent removal of cohesin from mitotic chromosomes.
  10. Smc5/6 is required to maintain stalled forks in a stable recombination-competent conformation primed for replication restart.
    Title: Smc5/6 maintains stalled replication forks in a recombination-competent conformation.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding ISM
Inferred from Sequence Model
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to topological DNA co-entrapment activity NAS
Non-traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Smc5-Smc6 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Smc5-Smc6 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Smc5-Smc6 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in division septum IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Smc5-6 complex SMC P-loop ATPase subunit Smc5

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    5226179..5229793 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001020338.3 → NP_594907.2  Smc5-6 complex SMC P-loop ATPase subunit Smc5 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594907.2

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O13710
    Conserved Domains (3) summary
    cd03277
    Location:946 → 1052
    ABC_SMC5_euk; ATP-binding cassette domain of eukaryotic SMC5 proteins
    COG1196
    Location:24 → 1067
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00901
    Location:632 → 884
    Orbi_VP5; Orbivirus outer capsid protein VP5
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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