cdr2 serine/threonine protein kinase Cdr2 [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

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Gene symbol: cdr2
Gene description: serine/threonine protein kinase Cdr2
Locus tag: SPOM_SPAC57A10.02
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Old locus tag: SPAC57A10.02
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Genomic context

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See cdr2 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 1

Sequence:: Chromosome: I; NC_003424.3 (1364796..1367968)

Chromosome I - NC_003424.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of cell size and Wee1 kinase by elevated levels of the cell cycle regulatory protein kinase Cdr2.
Title: Regulation of cell size and Wee1 kinase by elevated levels of the cell cycle regulatory protein kinase Cdr2.
Arf6 anchors Cdr2 nodes at the cell cortex to control cell size at division.
Title: Arf6 anchors Cdr2 nodes at the cell cortex to control cell size at division.
Cdr2 nodal density, which scales with cell size, is used by the cell to sense and control its size. By analyzing cells of different widths, the authors first show that cdr2(+) cells divide at a fixed cell surface area. However, division in the cdr2Delta mutant is more closely specified by cell volume.
Title: Reprogramming Cdr2-Dependent Geometry-Based Cell Size Control in Fission Yeast.
SIN-dependent phosphorylation of Cdr2 promotes its interaction with the 14-3-3 protein Rad24 that sequesters it in the cytoplasm during cell division.
Title: SIN-Dependent Dissociation of the SAD Kinase Cdr2 from the Cell Cortex Resets the Division Plane.
distinct levels in Pom1 gradients delineate a medial Cdr2 domain, for cell division placement, and control its activity, for mitotic commitment. [Pom1; Cdr2]
Title: Distinct levels in Pom1 gradients limit Cdr2 activity and localization to time and position division.
the association of Cdr2 effectors with different domains might constrain Cdr1 and Wee1 spatially to promote Wee1 inhibition upon Cdr2 kinase activation.
Title: Molecular control of the Wee1 regulatory pathway by the SAD kinase Cdr2.
Cdr2 was the only cell cycle target of Pom1 kinase activity that was identified in cells.
Title: Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
The dual regulation exerted by Pom1 on Cdr2 prevents Cdr2 assembly into stable nodes in the cell tip region where Pom1 concentration is high.
Title: Pom1 regulates the assembly of Cdr2-Mid1 cortical nodes for robust spatial control of cytokinesis.
Pom1 phosophorylated the C-terminal domain of Cdr2, and this modification reduced Cdr2-T166 phosphorylation by Ssp1
Title: Dueling kinases regulate cell size at division through the SAD kinase Cdr2.
Data show that the protein Skb1 interacted with both Cdr1 and the Cdr1 inhibitory target Wee1.
Title: Compartmentalized nodes control mitotic entry signaling in fission yeast.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by PomBase

Function	Evidence Code	Pubs
enables ATP binding	ISM Inferred from Sequence Model more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	EXP Inferred from Experiment more info	PubMed
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein-membrane adaptor activity	EXP Inferred from Experiment more info	PubMed
enables signaling adaptor activity	EXP Inferred from Experiment more info	PubMed

Process	Evidence Code	Pubs
involved_in mitotic G2 cell size control checkpoint signaling	EXP Inferred from Experiment more info	PubMed
involved_in mitotic G2 cell size control checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of G2/M transition of mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to medial cortical node	EXP Inferred from Experiment more info	PubMed
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Cdr2 medial cortical node complex	EXP Inferred from Experiment more info	PubMed
part_of Cdr2 medial cortical node complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in medial cortex	IDA Inferred from Direct Assay more info	PubMed
is_active_in medial cortical node	EXP Inferred from Experiment more info	PubMed
is_active_in medial cortical node	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitotic spindle pole body	HDA more info	PubMed
is_active_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: serine/threonine protein kinase Cdr2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003424.3 Reference assembly

Range

1364796..1367968

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001018737.3 → NP_593307.1 serine/threonine protein kinase Cdr2 [Schizosaccharomyces pombe]

See identical proteins and their annotated locations for NP_593307.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

P87050

Conserved Domains (3) summary

smart00220
Location:10 → 262

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14081
Location:8 → 262

STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2

pfam16797
Location:627 → 739

Fungal_KA1; Fungal kinase associated-1 domain