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sid2 serine/threonine protein kinase (NDR family) Sid2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541599, updated on 18-Sep-2024

Summary

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Official Symbol
sid2
Official Full Name
serine/threonine protein kinase (NDR family) Sid2
Primary source
PomBase:SPAC24B11.11c
Locus tag
SPOM_SPAC24B11.11C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See sid2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (221694..223953, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene chitin synthase regulatory factor-like Chr3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene phospholipid-transporting ATPase Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sid2p, a spindle pole body kinase that regulates the onset of cytokinesis. Sparks CA, et al. J Cell Biol, 1999 Aug 23. PMID 10459013, Free PMC Article
  2. Drc1p/Cps1p, a 1,3-beta-glucan synthase subunit, is essential for division septum assembly in Schizosaccharomyces pombe. Liu J, et al. Genetics, 1999 Nov. PMID 10545452, Free PMC Article
  3. Mob1p interacts with the Sid2p kinase and is required for cytokinesis in fission yeast. Hou MC, et al. Curr Biol, 2000 May 18. PMID 10837231
  4. Initiation of cytokinesis is controlled through multiple modes of regulation of the Sid2p-Mob1p kinase complex. Hou MC, et al. Mol Cell Biol, 2004 Apr. PMID 15060149, Free PMC Article
  5. The meiosis-specific Sid2p-related protein Slk1p regulates forespore membrane assembly in fission yeast. Yan H, et al. Mol Biol Cell, 2008 Sep. PMID 18562696, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These findings identify Mid1 as a key Sid2 substrate for SIN-mediated remodeling of the division site for efficient cytokinesis and provide evidence that nodes serve to integrate signals coordinating cell cycle progression and cytokinesis.
    Title: NDR Kinase Sid2 Drives Anillin-like Mid1 from the Membrane to Promote Cytokinesis and Medial Division Site Placement.
  2. Findings suggest that septins act as key players in an accurate establishment and the maintenance of contractile actomyosin ring (CAR) by orchestrating the equatorial dynamics of separation initiation network kinase Sid2p (Sid2p) and glucan synthases Bgs1p and Ags1p.
    Title: Septins regulate the equatorial dynamics of the separation initiation network kinase Sid2p and glucan synthases to ensure proper cytokinesis.
  3. We observe SIN-dependent disappearance of Klp2 from MTs in anaphase, and we find that this is mediated by direct phosphorylation of Klp2 by the SIN kinase Sid2, which abrogates loading of Klp2 onto MTs by inhibiting its interaction with Mal3
    Title: The kinesin-14 Klp2 is negatively regulated by the SIN for proper spindle elongation and telophase nuclear positioning.
  4. The fission yeast septation initiation network (SIN) kinase, Sid2, is required for SIN asymmetry and regulates the SIN scaffold, Cdc11.
    Title: The fission yeast septation initiation network (SIN) kinase, Sid2, is required for SIN asymmetry and regulates the SIN scaffold, Cdc11.
  5. Sid2 activation midway through G2 phase promotes Fin1 phosphorylation and mitotic commitment throught pom1/Wee1 cell geometry network.
    Title: The S. pombe cytokinesis NDR kinase Sid2 activates Fin1 NIMA kinase to control mitotic commitment through Pom1/Wee1.
  6. Slk1p and Sid2p play a role in forespore membrane assembly by facilitating recruitment of components of the secretory apparatus, such as Psy1p, to allow membrane expansion
    Title: The meiosis-specific Sid2p-related protein Slk1p regulates forespore membrane assembly in fission yeast.
  7. Sid2 maintains Clp1 in the cytoplasm in late mitosis by phosphorylating Clp1 directly and thereby creating binding sites for the 14-3-3 protein Rad24.
    Title: The SIN kinase Sid2 regulates cytoplasmic retention of the S. pombe Cdc14-like phosphatase Clp1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding ISM
Inferred from Sequence Model
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cytokinesis checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein localization to medial cortex EXP
Inferred from Experiment
more info
 PubMed 
involved_in positive regulation of G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitotic actomyosin contractile ring assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitotic actomyosin contractile ring contraction EXP
Inferred from Experiment
more info
 PubMed 
involved_in positive regulation of mitotic actomyosin contractile ring contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitotic spindle elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of nuclear migration during mitotic telophase IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of primary cell septum biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in septation initiation signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Sid2-Mob1 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in cell division site IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic actomyosin contractile ring IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic actomyosin contractile ring, intermediate layer IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic spindle pole body HDA PubMed 
is_active_in mitotic spindle pole body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in spindle pole body IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine protein kinase (NDR family) Sid2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    221694..223953 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018249.3 → NP_592848.1  serine/threonine protein kinase (NDR family) Sid2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_592848.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q09898
    Conserved Domains (2) summary
    smart00220
    Location:208 → 508
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05600
    Location:196 → 581
    STKc_Sid2p_like; Catalytic domain of Fungal Sid2p-like Protein Serine/Threonine Kinases
Nucleotide Protein
Heading Accession and Version

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