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lsk1 P-TEFb-associated cyclin-dependent protein kinase Lsk1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541672, updated on 18-Sep-2024

Summary

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Official Symbol
lsk1
Official Full Name
P-TEFb-associated cyclin-dependent protein kinase Lsk1
Primary source
PomBase:SPAC2F3.15
Locus tag
SPOM_SPAC2F3.15
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
ctk1
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Genomic context

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See lsk1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003424.3 (3953796..3956869)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ubiquitin-protein ligase E3 Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Histone H2B ubiquitylation represses gametogenesis by opposing RSC-dependent chromatin remodeling at the ste11 master regulator locus. Materne P, et al. Elife, 2016 May 12. PMID 27171419, Free PMC Article
  2. Functional interaction of Rpb1 and Spt5 C-terminal domains in co-transcriptional histone modification. Mbogning J, et al. Nucleic Acids Res, 2015 Nov 16. PMID 26275777, Free PMC Article
  3. TFIIH and P-TEFb coordinate transcription with capping enzyme recruitment at specific genes in fission yeast. Viladevall L, et al. Mol Cell, 2009 Mar 27. PMID 19328067, Free PMC Article
  4. Global gene expression analysis of fission yeast mutants impaired in Ser-2 phosphorylation of the RNA pol II carboxy terminal domain. Saberianfar R, et al. PLoS One, 2011. PMID 21931816, Free PMC Article
  5. The nuclear kinase Lsk1p positively regulates the septation initiation network and promotes the successful completion of cytokinesis in response to perturbation of the actomyosin ring in Schizosaccharomyces pombe. Karagiannis J, et al. Mol Biol Cell, 2005 Jan. PMID 15537703, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lsk1p, a nuclear-localized protein kinase, positively regulates the septation initiation network (SIN) and acts in parallel to Clp1p to promote actomyosin ring stability upon checkpoint activation. [Lsk1]
    Title: The nuclear kinase Lsk1p positively regulates the septation initiation network and promotes the successful completion of cytokinesis in response to perturbation of the actomyosin ring in Schizosaccharomyces pombe.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat S2 kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II CTD heptapeptide repeat S2 kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables RNA polymerase II CTD heptapeptide repeat kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II CTD heptapeptide repeat kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables cyclin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription elongation by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of CTDK-1 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cyclin/CDK positive transcription elongation factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear cyclin-dependent protein kinase holoenzyme complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in nucleolus HDA PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
P-TEFb-associated cyclin-dependent protein kinase Lsk1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    3953796..3956869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019816.3 → NP_594393.1  P-TEFb-associated cyclin-dependent protein kinase Lsk1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594393.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O14098
    Conserved Domains (2) summary
    smart00220
    Location:277 → 561
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07840
    Location:277 → 561
    STKc_CDK9_like; Catalytic domain of Cyclin-Dependent protein Kinase 9-like Serine/Threonine Kinases
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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