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cdc4 myosin II light chain cdc4 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541699, updated on 18-Sep-2024

Summary

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Official Symbol
cdc4
Official Full Name
myosin II light chain cdc4
Primary source
PomBase:SPAP8A3.08
Locus tag
SPOM_SPAP8A3.08
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See cdc4 in Genome Data Viewer
Location:
chromosome: I
Exon count:
5
Sequence:
Chromosome: I; NC_003424.3 (5329188..5331057)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene phospho-2-dehydro-3-deoxyheptonate aldolase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene serine/threonine protein phosphatase PP2A scaffold subunit Paa1 Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dissecting the domain structure of Cdc4p, a myosin essential light chain involved in Schizosaccharomyces pombe cytokinesis. Escobar-Cabrera E, et al. Biochemistry, 2005 Sep 13. PMID 16142912
  2. Structure of Cdc4p, a contractile ring protein essential for cytokinesis in Schizosaccharomyces pombe. Slupsky CM, et al. J Biol Chem, 2001 Feb 23. PMID 11087750
  3. Schizosaccharomyces pombe cdc4+ gene encodes a novel EF-hand protein essential for cytokinesis. McCollum D, et al. J Cell Biol, 1995 Aug. PMID 7622565, Free PMC Article
  4. Phosphorylation of the myosin-II light chain does not regulate the timing of cytokinesis in fission yeast. McCollum D, et al. J Biol Chem, 1999 Jun 18. PMID 10364209
  5. Evidence for F-actin-dependent and -independent mechanisms involved in assembly and stability of the medial actomyosin ring in fission yeast. Naqvi NI, et al. EMBO J, 1999 Feb 15. PMID 10022828, Free PMC Article

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a conformational plasticity of the C-domain, which may allow Cdc4p to interact with several regulatory or contractile ring proteins necessary for cytokinesis
    Title: Dissecting the domain structure of Cdc4p, a myosin essential light chain involved in Schizosaccharomyces pombe cytokinesis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
NOT enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitotic actomyosin contractile ring assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic actomyosin contractile ring assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell division site HDA PubMed 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in medial cortical node IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic actomyosin contractile ring IDA
Inferred from Direct Assay
more info
 PubMed 
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin II complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of myosin II complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in nucleus HDA PubMed 

General protein information

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Preferred Names
myosin II light chain cdc4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    5329188..5331057
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001020378.3 → NP_594947.1  myosin II light chain cdc4 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594947.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q09196
    Conserved Domains (3) summary
    PTZ00184
    Location:8 → 141
    PTZ00184; calmodulin; Provisional
    cd00051
    Location:78 → 138
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13405
    Location:8 → 36
    EF-hand_6; EF-hand domain
Nucleotide Protein
Heading Accession and Version

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