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nrd1 RNA-binding protein Nrd1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541755, updated on 18-Sep-2024

Summary

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Official Symbol
nrd1
Official Full Name
RNA-binding protein Nrd1
Primary source
PomBase:SPAC2F7.11
Locus tag
SPOM_SPAC2F7.11
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
msa2
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Genomic context

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See nrd1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (555286..559051)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene palmitoyltransferase Akr1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tryptophan-tRNA ligase Wrs1 Neighboring gene ncRNA Neighboring gene exosome subunit Rrp4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of the second RRM domain of Nrd1, a fission yeast MAPK target RNA binding protein, and implication for its RNA recognition and regulation. Kobayashi A, et al. Biochem Biophys Res Commun, 2013 Jul 19. PMID 23770370
  2. Role of the RNA-binding protein Nrd1 in stress granule formation and its implication in the stress response in fission yeast. Satoh R, et al. PLoS One, 2012. PMID 22276125, Free PMC Article
  3. Regulation and role of an RNA-binding protein Msa2 in controlling the sexual differentiation of fission yeast. Oowatari Y, et al. Curr Genet, 2011 Jun. PMID 21409593
  4. Isolation of a mammalian homologue of a fission yeast differentiation regulator. Yamamoto H, et al. Mol Cell Biol, 1999 May. PMID 10207106, Free PMC Article
  5. An RNA binding protein negatively controlling differentiation in fission yeast. Tsukahara K, et al. Mol Cell Biol, 1998 Aug. PMID 9671458, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The structure of the second RRM domain of Nrd1 was determined and the RNA binding site on the second RRM domain was mapped by NMR.
    Title: Structure of the second RRM domain of Nrd1, a fission yeast MAPK target RNA binding protein, and implication for its RNA recognition and regulation.
  2. Msa2 may regulate the translation of Ste11, be a component of stress granules that form in response to glucose starvation, and regulate the sexual differentiation of S. pombe.
    Title: Regulation and role of an RNA-binding protein Msa2 in controlling the sexual differentiation of fission yeast.
  3. Pmk1 mitogen-activated protein kinase (MAPK) directly phosphorylates Nrd1, thereby negatively regulating the binding activity of Nrd1 to Cdc4 mRNA.
    Title: Role of the RNA-binding protein Nrd1 and Pmk1 mitogen-activated protein kinase in the regulation of myosin mRNA stability in fission yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables poly(U) RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol HDA PubMed 
NOT is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
RNA-binding protein Nrd1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    555286..559051
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018382.3 → NP_592982.1  RNA-binding protein Nrd1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_592982.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q09702
    Conserved Domains (6) summary
    COG0724
    Location:86 → 344
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12520
    Location:114 → 187
    RRM1_MRN1; RNA recognition motif 1 of RNA-binding protein MRN1 and similar proteins
    cd12521
    Location:322 → 395
    RRM3_MRN1; RNA recognition motif 3 of RNA-binding protein MRN1 and similar proteins
    cd12522
    Location:411 → 489
    RRM4_MRN1; RNA recognition motif 4 of RNA-binding protein MRN1 and similar proteins
    cd12523
    Location:203 → 280
    RRM2_MRN1; RNA recognition motif 2 of RNA-binding protein MRN1 and similar proteins
    pfam10378
    Location:37 → 66
    RRM; Putative RRM domain
Nucleotide Protein
Heading Accession and Version

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