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prz1 calcineurin-responsive transcription factor Prz1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541806, updated on 18-Sep-2024

Summary

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Official Symbol
prz1
Official Full Name
calcineurin-responsive transcription factor Prz1
Primary source
PomBase:SPAC4G8.13c
Locus tag
SPOM_SPAC4G8.13C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See prz1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (786778..789912, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene alpha-1,2-mannosyltransferase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene carbohydrate kinase Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Neuronal calcium sensor-1 (Ncs1p) is up-regulated by calcineurin to promote Ca2+ tolerance in fission yeast. Hamasaki-Katagiri N, et al. J Biol Chem, 2010 Feb 12. PMID 20018864, Free PMC Article
  2. Valproic acid affects membrane trafficking and cell-wall integrity in fission yeast. Miyatake M, et al. Genetics, 2007 Apr. PMID 17287531, Free PMC Article
  3. cAMP-dependent protein kinase involves calcium tolerance through the regulation of Prz1 in Schizosaccharomyces pombe. Matsuo Y, et al. Biosci Biotechnol Biochem, 2017 Feb. PMID 27756188
  4. The role of the regulatory subunit of fission yeast calcineurin for in vivo activity and its relevance to FK506 sensitivity. Sio SO, et al. J Biol Chem, 2005 Apr 1. PMID 15657058
  5. Conserved and Diverged Functions of the Calcineurin-Activated Prz1 Transcription Factor in Fission Yeast. Chatfield-Reed K, et al. Genetics, 2016 Apr. PMID 26896331, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pka1 is essential for tolerance to exogenous CaCl2, probably because the expression level of Prz1 needs to be properly regulated by Pka1
    Title: cAMP-dependent protein kinase involves calcium tolerance through the regulation of Prz1 in Schizosaccharomyces pombe.
  2. This study reveals that Cmk1 kinase activated by the newly identified Ckk2 counteracts calcineurin function by negatively regulating Prz1 activity which in turn is involved in activating cmk1 gene transcription.
    Title: Negative feedback regulation of calcineurin-dependent Prz1 transcription factor by the CaMKK-CaMK1 axis in fission yeast.
  3. Rad24 and Rad25 negatively regulate Prz1 and that Pka1, Msn5, Pac1, Tfs1, and Ape2 also regulate Prz1.
    Title: Genetic screening for regulators of Prz1, a transcriptional factor acting downstream of calcineurin in fission yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables 14-3-3 protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcineurin-mediated signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in calcium-mediated signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to calcium ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular calcium ion homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in intracellular chloride ion homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
calcineurin-responsive transcription factor Prz1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    786778..789912 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018471.3 → NP_593073.1  calcineurin-responsive transcription factor Prz1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593073.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q09838
    Conserved Domains (4) summary
    COG5048
    Location:121 → 620
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:577 → 594
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:570 → 594
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:586 → 611
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
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