U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

htr12 serine protease [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541812, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
htr12
Official Full Name
serine protease
Primary source
PomBase:SPAC23G3.12c
Locus tag
SPOM_SPAC23G3.12C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See htr12 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (889058..892128, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ubiquitin hydrolase Ubp7 Neighboring gene ncRNA Neighboring gene transcription factor TFIID complex subunit Taf4 Neighboring gene SWI/SNF and RSC complex subunit Ssr3 Neighboring gene proteasome regulatory subunit Rpn6 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions. Nie M, et al. J Biol Chem, 2012 Aug 24. PMID 22730331, Free PMC Article
  2. Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries. Wang J, et al. Genes Dev, 2013 Sep 1. PMID 24013502, Free PMC Article
  3. Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes. Dixon SJ, et al. Proc Natl Acad Sci U S A, 2008 Oct 28. PMID 18931302, Free PMC Article
  4. A non-transcriptional role for the glucocorticoid receptor in mediating the cell stress response. Ptushkina M, et al. Sci Rep, 2017 Sep 21. PMID 28935859, Free PMC Article
  5. A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human. Vo TV, et al. Cell, 2016 Jan 14. PMID 26771498, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular lipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
serine protease

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    889058..892128 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018509.3 → NP_593112.1  serine protease [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593112.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O42705, Q9P7S1
    Conserved Domains (6) summary
    COG0265
    Location:38 → 369
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00987
    Location:289 → 365
    PDZ_serine_protease; PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind ...
    pfam12812
    Location:372 → 448
    PDZ_1; PDZ-like domain
    pfam13365
    Location:84 → 230
    Trypsin_2; Trypsin-like peptidase domain
    cl00117
    Location:844 → 919
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cl21584
    Location:551 → 698
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials