pub1 HECT-type ubiquitin-protein ligase E3 Pub1 [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

Gene symbol: pub1
Gene description: HECT-type ubiquitin-protein ligase E3 Pub1
Locus tag: SPOM_SPAC11G7.02
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Old locus tag: SPAC11G7.02
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Chromosome I - NC_003424.3 Genomic Context describing neighboring genes

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Environmental control of Pub1 (NEDD4 family E3 ligase) in Schizosaccharomyces pombe is regulated by TORC2 and Gsk3.
Title: Environmental control of Pub1 (NEDD4 family E3 ligase) in Schizosaccharomyces pombe is regulated by TORC2 and Gsk3.
a novel role for Pub1 in endocytosis of Ecm33 and regulation of cell wall integrity in fission yeast [Pub1][Ecm33]
Title: E3 ubiquitin ligase Pub1 is implicated in endocytosis of a GPI-anchored protein Ecm33 in fission yeast.
Pub1 altered the localization of the uracil transporter Fur4 from the Golgi locus and vacuoles to the plasma membrane.
Title: Cell Lysis in S. pombe ura4 Mutants Is Suppressed by Loss of Functional Pub1, Which Regulates the Uracil Transporter Fur4.
the TSC-Rheb signaling pathway regulates the localization of amino acid transporters via Pub1 and Any1 in a Tor2-independent manner.
Title: The fission yeast β-arrestin-like protein Any1 is involved in TSC-Rheb signaling and the regulation of amino acid transporters.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables phospholipid binding	ISM Inferred from Sequence Model more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoplasm to vacuole targeting by the NVT pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Golgi to plasma membrane protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of L-leucine import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of uracil import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	HDA more info	PubMed
is_active_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

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