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mes1 protein Mes1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541861, updated on 18-Sep-2024

Summary

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Official Symbol
mes1
Official Full Name
protein Mes1
Primary source
PomBase:SPAC5D6.08c
Locus tag
SPOM_SPAC5D6.08C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See mes1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
2
Sequence:
Chromosome: I; NC_003424.3 (1498898..1500084)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene protein mug116 Neighboring gene ncRNA Neighboring gene acetate transmembrane transporter Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fission yeast APC/C activators Slp1 and Fzr1 sequentially trigger two consecutive nuclear divisions during meiosis. Chikashige Y, et al. FEBS Lett, 2017 Apr. PMID 28245054
  2. Cuf2 boosts the transcription of APC/C activator Fzr1 to terminate the meiotic division cycle. Aoi Y, et al. EMBO Rep, 2013 Jun. PMID 23628763, Free PMC Article
  3. The RNA-binding protein Spo5 promotes meiosis II by regulating cyclin Cdc13 in fission yeast. Arata M, et al. Genes Cells, 2014 Mar. PMID 24506453
  4. A mutual inhibition between APC/C and its substrate Mes1 required for meiotic progression in fission yeast. Kimata Y, et al. Dev Cell, 2008 Mar. PMID 18331722
  5. Fission yeast Mes1p ensures the onset of meiosis II by blocking degradation of cyclin Cdc13p. Izawa D, et al. Nature, 2005 Mar 24. PMID 15791259

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mes1 interacts with two coactivators in a different way to control the activity of the APC/C required for the meiosis I/meiosis II transition.
    Title: Mes1 controls the meiosis I to meiosis II transition by distinctly regulating the anaphase-promoting complex/cyclosome coactivators Fzr1/Mfr1 and Slp1 in fission yeast.
  2. Mes1 is a substrate of the APC/C as well as an inhibitor, allowing autoregulation of the APC/C in meiosis.
    Title: A mutual inhibition between APC/C and its substrate Mes1 required for meiotic progression in fission yeast.
  3. Mes1p is a factor that suppresses the degradation of cyclin Cdc13p at anaphase I
    Title: Fission yeast Mes1p ensures the onset of meiosis II by blocking degradation of cyclin Cdc13p.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin ligase inhibitor activity EXP
Inferred from Experiment
more info
 PubMed 
enables ubiquitin ligase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in meiosis I/meiosis II transition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in metaphase/anaphase transition of meiosis I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of metaphase/anaphase transition of meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol HDA PubMed 
is_active_in nucleus HDA PubMed 

General protein information

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Preferred Names
protein Mes1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    1498898..1500084
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018793.3 → NP_593361.1  protein Mes1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593361.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P41005
Nucleotide Protein
Heading Accession and Version

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