cdc8 tropomyosin [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

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Official Symbol: cdc8
Official Full Name: tropomyosin
Primary source: PomBase:SPAC27F1.02c
Locus tag: SPOM_SPAC27F1.02C
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as: fus4
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Genomic context

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See cdc8 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 2

Sequence:: Chromosome: I; NC_003424.3 (4319247..4320235, complement)

Chromosome I - NC_003424.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data sugest that fimbrin (Fim1) competes with alpha-actinin (Ain1) for association with F-actin, and prevents tropomyosin Cdc8's association with actin patches.
Title: Cooperation between tropomyosin and α-actinin inhibits fimbrin association with actin filament networks in fission yeast.
Temperature sensitive point mutations in Cdc8 have long range effects on the stability and function of the actin-tropomyosin copolymer.
Title: Temperature sensitive point mutations in fission yeast tropomyosin have long range effects on the stability and function of the actin-tropomyosin copolymer.
Furthermore, Cdc8, Fim1, and Adf1 all compete for association with F-actin by different mechanisms, and their cooperative association with actin filaments affects their ability to compete.
Title: Competition between Tropomyosin, Fimbrin, and ADF/Cofilin drives their sorting to distinct actin filament networks.
The results of the present paper are consistent with acetylation providing a mechanism for modulating the formation and stability of Cdc8 polymers within the fission yeast cell.
Title: Altering the stability of the Cdc8 overlap region modulates the ability of this tropomyosin to bind co-operatively to actin and regulate myosin.
ng8 and Rng9 accumulate on the fusion focus, dependent on Myo51 and tropomyosin Cdc8. A tropomyosin mutant allele, which compromises Rng8/9 localization but not actin binding, similarly leads to multiple stable dots instead of a single focus.
Title: A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Myo52p lacking cargo, or single molecules of wild-type Myo52p with small cargoes, can undergo processive movement along actin-Cdc8p cables in vivo.
Title: Fission yeast tropomyosin specifies directed transport of myosin-V along actin cables.
A molecular evolution approach to study the roles of tropomyosin in fission yeast.
Title: A molecular evolution approach to study the roles of tropomyosin in fission yeast.
Data show that contractile ring assembly is delayed in Myo2p motor and tropomyosin mutants, but occurs prematurely in cells engineered to express two copies of myo2.
Title: Tropomyosin and myosin-II cellular levels promote actomyosin ring assembly in fission yeast.
Cdc12p can recruit SpTm to actin filaments and SpTm has diverse effects on Cdc12p-mediated actin assembly.
Title: Role of tropomyosin in formin-mediated contractile ring assembly in fission yeast.
Although acetylation of Cdc8 (tropomyosin) is not essential, it provides a regulatory mechanism for modulating actin filament integrity and myosin function.
Title: Acetylation regulates tropomyosin function in the fission yeast Schizosaccharomyces pombe.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by PomBase

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables actin lateral binding	IDA Inferred from Direct Assay more info	PubMed
enables molecular function regulator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cortical patch organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic actomyosin contractile ring assembly	EXP Inferred from Experiment more info	PubMed
involved_in mitotic actomyosin contractile ring contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of actin filament binding	IDA Inferred from Direct Assay more info	PubMed
involved_in plasma membrane fusion involved in cytogamy	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin cortical patch	IDA Inferred from Direct Assay more info	PubMed
is_active_in actin filament	IBA Inferred from Biological aspect of Ancestor more info
is_active_in actin filament	IDA Inferred from Direct Assay more info	PubMed
is_active_in actomyosin contractile ring	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cell division site	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	HDA more info	PubMed
is_active_in formin-nucleated actin cable	IDA Inferred from Direct Assay more info	PubMed
is_active_in mating projection actin fusion focus	IDA Inferred from Direct Assay more info	PubMed
is_active_in mating projection tip	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitotic actomyosin contractile ring	IDA Inferred from Direct Assay more info	PubMed