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tfs1 general transcription elongation factor TFIIS [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541941, updated on 18-Sep-2024

Summary

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Official Symbol
tfs1
Official Full Name
general transcription elongation factor TFIIS
Primary source
PomBase:SPAC20H4.03c
Locus tag
SPOM_SPAC20H4.03C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See tfs1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
5
Sequence:
Chromosome: I; NC_003424.3 (2114913..2116456, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene bromodomain-containing protein Neighboring gene ncRNA Neighboring gene U3 snoRNP-associated protein Utp5 Neighboring gene protein dsc3 Neighboring gene ATP-dependent 3'-5'-directionality DNA helicase fml2 Neighboring gene 5'-methylthioribulose-1-phosphate dehydratase Neighboring gene ncRNA Neighboring gene Gpl1-Gih35-Wdr83 complex RNA-binding subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tfs1, transcription elongation factor TFIIS, has an impact on chromosome segregation affected by pka1 deletion in Schizosaccharomyces pombe. Takenaka K, et al. Curr Genet, 2023 Jun. PMID 37052630
  2. The Rpb6 subunit of fission yeast RNA polymerase II is a contact target of the transcription elongation factor TFIIS. Ishiguro A, et al. Mol Cell Biol, 2000 Feb. PMID 10648612, Free PMC Article
  3. Defects in RNA quality control factors reveal RNAi-independent nucleation of heterochromatin. Reyes-Turcu FE, et al. Nat Struct Mol Biol, 2011 Sep 4. PMID 21892171, Free PMC Article
  4. The RNA exosome promotes transcription termination of backtracked RNA polymerase II. Lemay JF, et al. Nat Struct Mol Biol, 2014 Oct. PMID 25240800
  5. Genetic screening for regulators of Prz1, a transcriptional factor acting downstream of calcineurin in fission yeast. Koike A, et al. J Biol Chem, 2012 Jun 1. PMID 22496451, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription elongation factor activity NAS
Non-traceable Author Statement
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription elongation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
general transcription elongation factor TFIIS

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    2114913..2116456 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019054.3 → NP_593623.1  general transcription elongation factor TFIIS [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593623.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P49373
    Conserved Domains (4) summary
    cd00183
    Location:3 → 78
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
    cd13749
    Location:246 → 292
    Zn-ribbon_TFIIS; domain III/zinc ribbon domain of Transcription Factor IIS
    TIGR01385
    Location:3 → 293
    TFSII; transcription elongation factor S-II
    pfam07500
    Location:131 → 237
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
Nucleotide Protein
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