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plo1 Polo kinase Plo1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541957, updated on 18-Sep-2024

Summary

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Official Symbol
plo1
Official Full Name
Polo kinase Plo1
Primary source
PomBase:SPAC23C11.16
Locus tag
SPOM_SPAC23C11.16
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See plo1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (2164231..2166765)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ER zinc importer, CDF family, Zhf1 Neighboring gene Clr6 histone deacetylase complex subunit Pst2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene putative potassium ion transporter Mdm28 Neighboring gene ncRNA Neighboring gene mismatch repair ATPase msh1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Plo1(+) regulates gene transcription at the M-G(1) interval during the fission yeast mitotic cell cycle. Anderson M, et al. EMBO J, 2002 Nov 1. PMID 12411492, Free PMC Article
  2. Plo1 kinase recruitment to the spindle pole body and its role in cell division in Schizosaccharomyces pombe. Mulvihill DP, et al. Mol Biol Cell, 1999 Aug. PMID 10436027, Free PMC Article
  3. The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring, and septum, can drive septum formation in G1 and G2 cells. Ohkura H, et al. Genes Dev, 1995 May 1. PMID 7744248
  4. Redistribution of centrosomal proteins by centromeres and Polo kinase controls partial nuclear envelope breakdown in fission yeast. Bestul AJ, et al. Mol Biol Cell, 2021 Aug 1. PMID 34133218, Free PMC Article
  5. Analysis of S. pombe SIN protein association to the SPB reveals two genetically separable states of the SIN. Wachowicz P, et al. J Cell Sci, 2015 Feb 15. PMID 25501816

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Redistribution of centrosomal proteins by centromeres and Polo kinase controls partial nuclear envelope breakdown in fission yeast.
    Title: Redistribution of centrosomal proteins by centromeres and Polo kinase controls partial nuclear envelope breakdown in fission yeast.
  2. Study shows that fission yeast Moa1 (meikin), which associates stably with CENP-C during meiosis I, recruits Plo1 (polo-like kinase) to the kinetochores and phosphorylates Spc7 (KNL1) to accumulate Bub1. Consequently, in contrast to the transient kinetochore localization of mitotic Bub1, meiotic Bub1 persists at kinetochores until anaphase I.
    Title: Meikin-associated polo-like kinase specifies Bub1 distribution in meiosis I.
  3. The data presented in this study suggest there are at least two, genetically separable, states of the septation initiation network; an early state that is dependent upon Plo1p for its establishment, and a late state, which is dependent upon Spg1p.
    Title: Analysis of S. pombe SIN protein association to the SPB reveals two genetically separable states of the SIN.
  4. Substitution of a conserved methionine residue to phenylalanine in Plo1, Orb5 and Wee1 kinases increased the sensitivities to ATP analogues.
    Title: Mutation of a conserved residue enhances the sensitivity of analogue-sensitised kinases to generate a novel approach to the study of mitosis in fission yeast.
  5. PP1 recruitment to Cut12 sets a threshold for Polo's feedback-loop activity that locks the cell in interphase until Cdc25 pushes MPF activity through this barrier to initiate mitosis.
    Title: Removal of centrosomal PP1 by NIMA kinase unlocks the MPF feedback loop to promote mitotic commitment in S. pombe.
  6. Dam1 phosphorylation by Plo1 is dispensable for DASH assembly and chromosome retrieval but instead aids tension-dependent chromosome bi-orientation
    Title: Plo1 phosphorylates Dam1 to promote chromosome bi-orientation in fission yeast.
  7. Plo1 and a centrin play central roles in the meiotic spindle pole body remodeling
    Title: Spindle pole body components are reorganized during fission yeast meiosis.
  8. Plo1 facilitates contractile ring assembly at mitotic onset by regulating myosin II recruitment by Mid1/anillin.
    Title: Temporal control of contractile ring assembly by Plo1 regulation of myosin II recruitment by Mid1/anillin.
  9. pericentrin-like Pcp1 regulates multiple functions of the spindle pole body (SPB) through recruiting two critical factors, the gamma-tubulin complex (gamma-TuC) and polo kinase (Plo1)
    Title: Fission yeast Pcp1 links polo kinase-mediated mitotic entry to gamma-tubulin-dependent spindle formation.
  10. Plo1p controls M-G1-phase gene transcription through a combination of phosphorylation and cell-cycle-specific DNA binding to Pombe cell cycle boxes.
    Title: Regulation of gene expression during M-G1-phase in fission yeast through Plo1p and forkhead transcription factors.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in homologous chromosome orientation in meiotic metaphase I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in homologous chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic centromere clustering IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic centromeric cohesion protection in anaphase I EXP
Inferred from Experiment
more info
 PubMed 
involved_in meiotic centromeric cohesion protection in anaphase I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic spindle pole body organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell size IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitotic division septum assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitotic metaphase/anaphase transition IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of mitotic sister chromatid biorientation IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in positive regulation of protein export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of septation initiation signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitotic actomyosin contractile ring assembly EXP
Inferred from Experiment
more info
 PubMed 
involved_in spindle attachment to meiosis I kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol HDA PubMed 
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in meiotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in meiotic spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in meiotic spindle pole body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic spindle midzone IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic spindle pole body HDA PubMed 
is_active_in mitotic spindle pole body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleolar peripheral inclusion body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in spindle pole body IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Polo kinase Plo1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    2164231..2166765
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019078.3 → NP_593647.1  Polo kinase Plo1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593647.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P50528
    Conserved Domains (4) summary
    smart00220
    Location:41 → 296
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13117
    Location:599 → 676
    POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cd13118
    Location:490 → 580
    POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cd14099
    Location:41 → 296
    STKc_PLK; Catalytic domain of the Serine/Threonine Kinases, Polo-like kinases
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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