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cka1 serine/threonine protein kinase Cka1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541972, updated on 22-Jun-2024

Summary

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Gene symbol
cka1
Gene description
serine/threonine protein kinase Cka1
Locus tag
SPOM_SPAC23C11.11
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
orb5
Old locus tag
SPAC23C11.11
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Genomic context

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See cka1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
5
Sequence:
Chromosome: I; NC_003424.3 (2152037..2154223)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene alanine--tRNA (Ala) ligase Ala1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 3'-5'-RNA exonuclease Mpn1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene anaphase-promoting complex TPR lobe accessory factor subunit Hcn1/Apc12 Neighboring gene xanthine phosphoribosyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Casein kinase II-dependent phosphorylation of DNA topoisomerase II suppresses the effect of a catalytic topo II inhibitor, ICRF-193, in fission yeast. Nakazawa N, et al. J Biol Chem, 2019 Mar 8. PMID 30635402, Free PMC Article
  2. Genetic analysis of cell morphogenesis in fission yeast--a role for casein kinase II in the establishment of polarized growth. Snell V, et al. EMBO J, 1994 May 1. PMID 8187760, Free PMC Article
  3. Casein kinase II is required for the spindle assembly checkpoint by regulating Mad2p in fission yeast. Shimada M, et al. Biochem Biophys Res Commun, 2009 Oct 23. PMID 19666000
  4. The Schizosaccharomyces pombe casein kinase II alpha and beta subunits: evolutionary conservation and positive role of the beta subunit. Roussou I, et al. Mol Cell Biol, 1994 Jan. PMID 8264625, Free PMC Article
  5. Phosphoregulation of the cytokinetic protein Fic1 contributes to fission yeast growth polarity establishment. Bohnert KA, et al. J Cell Sci, 2020 Sep 17. PMID 32878942, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Substitution of a conserved methionine residue to phenylalanine in Plo1, Orb5 and Wee1 kinases increased the sensitivities to ATP analogues.
    Title: Mutation of a conserved residue enhances the sensitivity of analogue-sensitised kinases to generate a novel approach to the study of mitosis in fission yeast.
  2. These results suggest that CK2 has a role in the spindle checkpoint by regulating Mad2p.
    Title: Casein kinase II is required for the spindle assembly checkpoint by regulating Mad2p in fission yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding ISM
Inferred from Sequence Model
more info
  
enables protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment or maintenance of cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of establishment or maintenance of bipolar cell polarity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of mRNA splicing, via spliceosome EXP
Inferred from Experiment
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase I IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase III IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signaling NAS
Non-traceable Author Statement
more info
  
Component Evidence Code Pubs
part_of UTP-C complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cell tip IDA
Inferred from Direct Assay
more info
 PubMed 
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in division septum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic spindle pole body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleolus HDA PubMed 
is_active_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein kinase CK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein kinase CK2 complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine protein kinase Cka1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    2152037..2154223
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019073.3 → NP_593642.1  serine/threonine protein kinase Cka1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593642.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P40231
    Conserved Domains (2) summary
    smart00220
    Location:43 → 328
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14132
    Location:24 → 329
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
Nucleotide Protein
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