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tgs1 RNA methyltransferase Tgs1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542015, updated on 18-Sep-2024

Summary

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Official Symbol
tgs1
Official Full Name
RNA methyltransferase Tgs1
Primary source
PomBase:SPAC2G11.15c
Locus tag
SPOM_SPAC2G11.15C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
SPAC521.01c; tgs2
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Genomic context

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See tgs1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003424.3 (841471..842625, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene vacuolar amino acid transmembrane transporter Atg22 Neighboring gene transcription factor TFIID complex, histone acetyltransferase subunit Taf111 Neighboring gene ncRNA Neighboring gene dehydrogenase Neighboring gene DNA repair WLM domain metallopeptidase Wss1 Neighboring gene calcium permease

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Biochemical and genetic analysis of RNA cap guanine-N2 methyltransferases from Giardia lamblia and Schizosaccharomyces pombe. Hausmann S, et al. Nucleic Acids Res, 2007. PMID 17284461, Free PMC Article
  2. Specificity and mechanism of RNA cap guanine-N2 methyltransferase (Tgs1). Hausmann S, et al. J Biol Chem, 2005 Feb 11. PMID 15590684
  3. The fission yeast ortholog of Coilin, Mug174, forms Cajal body-like nuclear condensates and is essential for cellular quiescence. Deng X, et al. Nucleic Acids Res, 2024 Aug 27. PMID 38828770, Free PMC Article
  4. Mtr4-like protein coordinates nuclear RNA processing for heterochromatin assembly and for telomere maintenance. Lee NN, et al. Cell, 2013 Nov 21. PMID 24210919, Free PMC Article
  5. Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase. Chen JS, et al. Mol Cell Proteomics, 2013 May. PMID 23297348, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mapping the Tgs2 active site by mutagenesis.
    Title: Biochemical and genetic analysis of RNA cap guanine-N2 methyltransferases from Giardia lamblia and Schizosaccharomyces pombe.
  2. The methyltransferase Tgs1, a catalyst of TMG cap synthesis, is guanine-specific; N7 methylation must precede N2 methylation; it acts via a distributive mechanism; and the chemical steps of TMG synthesis do not require RNA or protein cofactors. [Tgs1]
    Title: Specificity and mechanism of RNA cap guanine-N2 methyltransferase (Tgs1).
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables RNA cap trimethylguanosine synthase activity EXP
Inferred from Experiment
more info
 PubMed 
enables RNA cap trimethylguanosine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA cap trimethylguanosine synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in 7-methylguanosine cap hypermethylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 7-methylguanosine cap hypermethylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Cajal body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm HDA PubMed 
is_active_in cytosol HDA PubMed 
is_active_in mitotic spindle HDA PubMed 
is_active_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RNA methyltransferase Tgs1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    841471..842625 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018493.4 → NP_593095.3  RNA methyltransferase Tgs1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593095.3

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P78826, Q09814, Q9P7B6
    Conserved Domains (1) summary
    pfam09445
    Location:74 → 232
    Methyltransf_15; RNA cap guanine-N2 methyltransferase
Nucleotide Protein
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Gene LinkOut

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Molecular Biology Databases
Research Materials