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hrq1 RecQ type DNA helicase Hrq1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542036, updated on 18-Sep-2024

Summary

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Official Symbol
hrq1
Official Full Name
RecQ type DNA helicase Hrq1
Primary source
PomBase:SPAC23A1.19c
Locus tag
SPOM_SPAC23A1.19C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
SPAC26H5.01c
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Genomic context

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See hrq1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
2
Sequence:
Chromosome: I; NC_003424.3 (4113673..4117214, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene mitochondrial 37S ribosomal protein bS1m Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DNA replication ATPase Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tdp1 processes chromate-induced single-strand DNA breaks that collapse replication forks. Ganguly A, et al. PLoS Genet, 2018 Aug. PMID 30148840, Free PMC Article
  2. The RecQ4 orthologue Hrq1 is critical for DNA interstrand cross-link repair and genome stability in fission yeast. Groocock LM, et al. Mol Cell Biol, 2012 Jan. PMID 22064477, Free PMC Article
  3. Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth. Rallis C, et al. Biol Open, 2014 Feb 15. PMID 24463365, Free PMC Article
  4. Large scale screening of genetic interaction with sgf73(+) in fission yeast. Guo Y, et al. Yi Chuan, 2014 Jul. PMID 25076038
  5. Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast. Roguev A, et al. Science, 2008 Oct 17. PMID 18818364, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cells lacking Hrq1 suffer spontaneous genomic instability and, consequently, require homologous recombination repair and the DNA damage checkpoint for viability.
    Title: The RecQ4 orthologue Hrq1 is critical for DNA interstrand cross-link repair and genome stability in fission yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3'-5' DNA helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding ISM
Inferred from Sequence Model
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables bubble DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in UV-damage excision repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in interstrand cross-link repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleotide-excision repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleotide-excision repair IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in nucleotide-excision repair involved in interstrand cross-link repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
RecQ type DNA helicase Hrq1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    4113673..4117214 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019877.3 → NP_594448.2  RecQ type DNA helicase Hrq1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594448.2

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O13983, O42856
    Conserved Domains (5) summary
    smart01075
    Location:51 → 222
    CDT1; DNA replication factor CDT1 like
    COG1205
    Location:257 → 1063
    YprA; ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair]
    pfam00270
    Location:313 → 490
    DEAD; DEAD/DEAH box helicase
    pfam00271
    Location:531 → 653
    Helicase_C; Helicase conserved C-terminal domain
    pfam09369
    Location:915 → 1007
    DUF1998; Domain of unknown function (DUF1998)
Nucleotide Protein
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Gene LinkOut

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Molecular Biology Databases
Research Materials