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pcr1 DNA-binding transcription factor Pcr1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542047, updated on 18-Sep-2024

Summary

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Official Symbol
pcr1
Official Full Name
DNA-binding transcription factor Pcr1
Primary source
PomBase:SPAC21E11.03c
Locus tag
SPOM_SPAC21E11.03C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
mts2
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Genomic context

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See pcr1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (4252142..4253600, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene aldose reductase ARK13 family YakC, implicated in cellular detoxification from family members Neighboring gene 60S ribosomal protein uL2 Neighboring gene ncRNA Neighboring gene L-azetidine-2-carboxylic acid acetyltransferase Aca1 Neighboring gene cyclophilin family peptidyl-prolyl cis-trans isomerase Cyp8 Neighboring gene ncRNA Neighboring gene translation initiation factor eIF2B delta subunit tif224

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A heteromeric protein that binds to a meiotic homologous recombination hot spot: correlation of binding and hot spot activity. Wahls WP, et al. Genes Dev, 1994 Jul 15. PMID 7958849
  2. Correlation of Meiotic DSB Formation and Transcription Initiation Around Fission Yeast Recombination Hotspots. Yamada S, et al. Genetics, 2017 Jun. PMID 28396503, Free PMC Article
  3. Functional significance of nuclear export and mRNA binding of meiotic regulator Spo5 in fission yeast. Togashi N, et al. BMC Microbiol, 2014 Jul 15. PMID 25023750, Free PMC Article
  4. Distinct regions of ATF/CREB proteins Atf1 and Pcr1 control recombination hotspot ade6-M26 and the osmotic stress response. Gao J, et al. Nucleic Acids Res, 2008 May. PMID 18375981, Free PMC Article
  5. Atf1-Pcr1-M26 complex links stress-activated MAPK and cAMP-dependent protein kinase pathways via chromatin remodeling of cgs2+. Davidson MK, et al. J Biol Chem, 2004 Dec 3. PMID 15448137, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. study presents evidence in favour of selective inhibition of Atf1's ability to activate cdc13+ transcription; show that Pcr1 can specifically inhibit the recruitment of Atf1 on cdc13 promoter thereby preventing Atf1-mediated mitotic acceleration; also show that this opposition of Atf1 functions by Pcr1 extends to the G1-S transition event
    Title: Antagonistic regulation of cyclin expression by the bZIP transcription factors Pcr1 and Atf1 during G2/M transition.
  2. A group of hotspots in fission yeast are associated with sequences similar to the cyclic AMP response element and activated by the ATF/CREB family transcription factor dimer Atf1-Pcr1.
    Title: Correlation of Meiotic DSB Formation and Transcription Initiation Around Fission Yeast Recombination Hotspots.
  3. The data indicate that Atf1 and Pcr1 induce the transcription of agl1, which allows efficient utilization of extracellular maltose.
    Title: The transcription factors Atf1 and Pcr1 are essential for transcriptional induction of the extracellular maltase Agl1 in fission yeast.
  4. Responses to stresses of cells lacking either Pcr1 or Atf1 do not fully overlap, and most Atf1-dependent genes induced by osmotic stress are Pcr1 dependent, some genes require only the presence of Atf1 for their induction.
    Title: Transcription factors Pcr1 and Atf1 have distinct roles in stress- and Sty1-dependent gene regulation.
  5. Pcr1 confers DNA-binding site specificity for the Atf1-Pcr1 heterodimer.
    Title: Distinct regions of ATF/CREB proteins Atf1 and Pcr1 control recombination hotspot ade6-M26 and the osmotic stress response.
  6. Both Atf1 and its binding partner Pcr1 are required for association of Sty1 with Atf1-dependent promoters, suggesting that this heterodimer must be intact for optimal recruitment of the MAPK
    Title: Fission yeast MAP kinase Sty1 is recruited to stress-induced genes.
  7. Atf1 and Pcr1, two ATF/CREB family proteins, act in a parallel mechanism to the RNA interference pathway for heterochromatin nucleation
    Title: RNAi-independent heterochromatin nucleation by the stress-activated ATF/CREB family proteins.
  8. the Atf1-Pcr1-M26 complex links stress-activated MAPK and cAMP-dependent protein kinase pathways via chromatin remodeling of cgs2+
    Title: Atf1-Pcr1-M26 complex links stress-activated MAPK and cAMP-dependent protein kinase pathways via chromatin remodeling of cgs2+.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific EXP
Inferred from Experiment
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables recombination hotspot binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in siRNA-mediated heterochromatin formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in silent mating-type cassette heterochromatin formation EXP
Inferred from Experiment
more info
 PubMed 
involved_in silent mating-type cassette heterochromatin formation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of atf1-pcr1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic spindle HDA PubMed 
is_active_in nucleus HDA PubMed 

General protein information

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Preferred Names
DNA-binding transcription factor Pcr1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    4252142..4253600 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019929.3 → NP_594500.1  DNA-binding transcription factor Pcr1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594500.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q09926
    Conserved Domains (1) summary
    cd14687
    Location:12 → 72
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials