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tif224 translation initiation factor eIF2B delta subunit tif224 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542064, updated on 18-Sep-2024

Summary

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Official Symbol
tif224
Official Full Name
translation initiation factor eIF2B delta subunit tif224
Primary source
PomBase:SPAC21E11.06
Locus tag
SPOM_SPAC21E11.06
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See tif224 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (4257700..4259783)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DNA-binding transcription factor Pcr1 Neighboring gene L-azetidine-2-carboxylic acid acetyltransferase Aca1 Neighboring gene cyclophilin family peptidyl-prolyl cis-trans isomerase Cyp8 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene iron-sulfur cluster biogenesis IBA57-like protein Neighboring gene serine palmitoyltransferase Lcb2 Neighboring gene Sm snRNP core protein Smd2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural basis for eIF2B inhibition in integrated stress response. Kashiwagi K, et al. Science, 2019 May 3. PMID 31048492
  2. Crystal structure of eukaryotic translation initiation factor 2B. Kashiwagi K, et al. Nature, 2016 Mar 3. PMID 26901872
  3. Expression, purification, and crystallization of Schizosaccharomyces pombe eIF2B. Kashiwagi K, et al. J Struct Funct Genomics, 2016 Mar. PMID 27023709, Free PMC Article
  4. Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries. Wang J, et al. Genes Dev, 2013 Sep 1. PMID 24013502, Free PMC Article
  5. A non-transcriptional role for the glucocorticoid receptor in mediating the cell stress response. Ptushkina M, et al. Sci Rep, 2017 Sep 21. PMID 28935859, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables translation initiation factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translational initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in translational initiation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol HDA PubMed 
part_of eukaryotic translation initiation factor 2B complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
translation initiation factor eIF2B delta subunit tif224

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    4257700..4259783
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019932.3 → NP_594503.1  translation initiation factor eIF2B delta subunit tif224 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594503.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q09924
    Conserved Domains (1) summary
    pfam01008
    Location:156 → 451
    IF-2B; Initiation factor 2 subunit family
Nucleotide Protein
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